The combination of nanofibrous and microfibrous materials for enhancement of cell infiltration and in vivo bone tissue formation

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F46747885%3A24410%2F18%3A00005125" target="_blank" >RIV/46747885:24410/18:00005125 - isvavai.cz</a>
Alternative codes found
RIV/68378041:_____/18:00482682 RIV/68407700:21720/18:00317967 RIV/00216208:11140/18:10371938
Result on the web
<a href="https://doi.org/10.1088/1748-605X/aa9717" target="_blank" >https://doi.org/10.1088/1748-605X/aa9717</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1088/1748-605X/aa9717" target="_blank" >10.1088/1748-605X/aa9717</a>

Result language
angličtina
Original language name
The combination of nanofibrous and microfibrous materials for enhancement of cell infiltration and in vivo bone tissue formation
Original language description
Fibrous scaffolds are desired in tissue engineering applications for their ability to mimic extracellular matrix. In this study we compared fibrous scaffolds prepared from polycaprolactone using three different fabrication methods, electrospinning (ES), electro-blowing and melt-blown combined with ES. Scaffolds differed in morphology, fiber diameters and pore sizes. Mesenchymal stem cell adhesion, proliferation and osteogenic differentiation on scaffolds was evaluated. The most promising scaffold was shown to be melt-blown in combination with ES which combined properties of both technologies. Microfibers enabled good cell infiltration and nanofibers enhanced cell adhesion. This scaffold was used for further testing in critical sized defects in rabbits. New bone tissue formation occurred from the side of the treated defects, compared to a control group where only fat tissue was present. Polycaprolactone fibrous scaffold prepared using a combination of melt-blown and ES technology seems to be promising for bone regeneration. The practical application of results is connected with enormous production capacity and low cost of materials produced by melt-blown technology, compared to other bone scaffold fabrication methods.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10608 - Biochemistry and molecular biology

Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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