Formulating Smart All-in-One Chitosan Hydrogel for High Performance Wound Dressing
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F46747885%3A24410%2F26%3A00013747" target="_blank" >RIV/46747885:24410/26:00013747 - isvavai.cz</a>
Result on the web
<a href="https://doi.org/10.1002/adhm.202502971" target="_blank" >https://doi.org/10.1002/adhm.202502971</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/adhm.202502971" target="_blank" >10.1002/adhm.202502971</a>
Alternative languages
Result language
angličtina
Original language name
Formulating Smart All-in-One Chitosan Hydrogel for High Performance Wound Dressing
Original language description
The poor mechanical and film formation properties of chitosan hydrogel limit its application as a wound dressing. To solve this shortcoming, chitosan-graft-poly(N-isopropyl acrylamide) (PNIPAAm) and crosslinked with polyvinyl alcohol/polyvinyl pyrollidone (PVA/PVP) blend polymer is designed to form the thermosensitive hydrogel. After that, silver nanoparticles (AgNPs), synthesized by the co-reduction method, are added into the chitosan hydrogel network to provide better antibacterial ability. When the temperature is above 32 degrees C, the hydrogel showed a decrease in particle size and transmittance, which proved that it is a thermal responsive material. Chitosan hydrogels are evaluated for their thermal properties, mechanical properties, swelling effects, antibacterial properties, and wound healing ability in rats. The results show that the hydrogel has a large number of intermolecular and intramolecular hydrogen bonds and a porous 3D network structure. The swelling ratio is 358.86 +/- 23.56% and the degradation ratio is 86.02 +/- 2.82% at 21 days. It also has excellent antibacterial properties against Escherichia coli and a much faster wound recovery ability. Therefore, a chitosan hydrogel with excellent physical properties is formulated in this study and has great potential as a smart all-in-one wound dressing for accelerating wound healing.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
20901 - Industrial biotechnology
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2026
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
ADVANCED HEALTHCARE MATERIALS>
ISSN
2192-2640
e-ISSN
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Volume of the periodical
15
Issue of the periodical within the volume
4
Country of publishing house
GB - UNITED KINGDOM
Number of pages
14
Pages from-to
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UT code for WoS article
001587800500001
EID of the result in the Scopus database
2-s2.0-105018323056