Nanofibrous scaffolds in skin tissue engineering and wound healing based on synthetic polymers

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F46747885%3A24510%2F19%3A00007103" target="_blank" >RIV/46747885:24510/19:00007103 - isvavai.cz</a>

Result on the web

<a href="https://www.intechopen.com/online-first/nanofibrous-scaffolds-for-skin-tissue-engineering-and-wound-healing-based-on-synthetic-polymers" target="_blank" >https://www.intechopen.com/online-first/nanofibrous-scaffolds-for-skin-tissue-engineering-and-wound-healing-based-on-synthetic-polymers</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.5772/intechopen.88744" target="_blank" >10.5772/intechopen.88744</a>

Result language

angličtina

Original language name

Nanofibrous scaffolds in skin tissue engineering and wound healing based on synthetic polymers

Original language description

Nanofibrous scaffolds are popular materials in all areas of tissue engineering, because they mimic the fibrous component of the natural extracellular matrix. In this chapter, we focused on the application of nanofibers in skin tissue engineering and wound healing, because the skin is an organ with several vitally important functions, particularly barrier, thermoregulatory, and sensory functions. Nanofibrous meshes not only serve as carriers for skin cells but also can prevent the penetration of microbes into wounds and can keep appropriate moisture in the damaged skin. The nanofibrous meshes have been prepared from a wide range of synthetic and nature-derived polymers. This review is concentrated on synthetic non-degradable and degradable polymers, which have been explored for skin tissue engineering and wound healing. These synthetic polymers were often combined with natural polymers of the protein or polysaccharide nature, which improved their attractiveness for cell colonization. The nanofibrous scaffolds can also be loaded with various bioactive molecules, such as growth factors, hormones, vitamins, antioxidants, antimicrobial, and antitumor agents. In advanced tissue engineering approaches, the cells on the nanofibrous scaffolds are cultured in dynamic bioreactors enabling appropriate mechanical stimulation of cells and at air-liquid interface. This chapter summarizes recent results achieved in the field of nanofiber-based skin tissue engineering, including results of our research group.

Czech name

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Czech description

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Type

C - Chapter in a specialist book

CEP classification

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OECD FORD branch

21001 - Nano-materials (production and properties)

Project

<a href="/en/project/GA17-02448S" target="_blank" >GA17-02448S: Improved growth of human skin cells on biomimetic nanofibrous matrices for active wound healing</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2019

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Book/collection name

Applications of Nanobiotechnology

ISBN

978-1-78985-978-2

Number of pages of the result

29

Pages from-to

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Number of pages of the book

1000

Publisher name

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Place of publication

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UT code for WoS chapter

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