High-throughput fabrication, structural characterization, and cellular interaction of compositionally diverse fish gelatin/polycaprolactone (PCL) nanofibrous materials

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F46747885%3A24510%2F23%3A00011343" target="_blank" >RIV/46747885:24510/23:00011343 - isvavai.cz</a>

Result on the web

<a href="https://onlinelibrary.wiley.com/doi/10.1002/app.54376" target="_blank" >https://onlinelibrary.wiley.com/doi/10.1002/app.54376</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/app.54376" target="_blank" >10.1002/app.54376</a>

Result language

angličtina

Original language name

High-throughput fabrication, structural characterization, and cellular interaction of compositionally diverse fish gelatin/polycaprolactone (PCL) nanofibrous materials

Original language description

Nanofibers made by blending natural and synthetic biopolymers have shown promise for better mechanical stability, ECM morphology mimicry, and cellular interaction of such materials. With the evolution of production methods of nanofibers, alternating field electrospinning (a.k.a. alternating current (AC) electrospinning) demonstrates a strong potential for scalable and sustainable fabrication of nanofibrous materials. This study focuses on AC-electrospinning of poorly miscible blends of gelatin from cold water fish skin (FGEL) and polycaprolactone (PCL) in a range of FGEL/PCL mass ratios from 0.9:0.1 to 0.4:0.6 in acetic acid single-solvent system. The nanofiber productivity rates of 7.8-19.0 g/h were obtained using a single 25 mm diameter dish-like spinneret, depending on the precursor composition. The resulting nanofibrous meshes had 94%-96% porosity and revealed the nanofibers with 200-750 nm diameters and smooth surface morphology. The results of FTIR, XRD, and water contact angle analyses have shown the effect of FGEL/PCL mass ratio on the changes in the material wettability, PCL crystallinity and orientation of PCL crystalline regions, and secondary structure of FGEL in as-spun and thermally crosslinked materials. Preliminary in vitro tests with 3 T3 mouse fibroblasts confirmed favorable and tunable cell attachment, proliferation, and spreading on all tested FGEL/PCL nanofibrous meshes.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

10404 - Polymer science

Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2023

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

JOURNAL OF APPLIED POLYMER SCIENCE

ISSN

0021-8995

e-ISSN

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Volume of the periodical

140

Issue of the periodical within the volume

JUL 3

Country of publishing house

US - UNITED STATES

Number of pages

15

Pages from-to

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UT code for WoS article

001022733200001

EID of the result in the Scopus database

2-s2.0-85164306435