Effect of Non-Modified as Well as Surface-Modified SiO2 Nanoparticles on Red Blood Cells, Biological and Model Membranes
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F46747885%3A24510%2F23%3A00011344" target="_blank" >RIV/46747885:24510/23:00011344 - isvavai.cz</a>
Result on the web
<a href="https://www.mdpi.com/1422-0067/24/14/11760" target="_blank" >https://www.mdpi.com/1422-0067/24/14/11760</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3390/ijms241411760" target="_blank" >10.3390/ijms241411760</a>
Alternative languages
Result language
angličtina
Original language name
Effect of Non-Modified as Well as Surface-Modified SiO2 Nanoparticles on Red Blood Cells, Biological and Model Membranes
Original language description
Nanoparticles are extremely promising components that are used in diagnostics and medical therapies. Among them, silica nanoparticles are ultrafine materials that, due to their unique physicochemical properties, have already been used in biomedicine, for instance, in cancer therapy. The aim of this study was to investigate the cytotoxicity of three types of nanoparticles ((Formula presented.), (Formula presented.), and (Formula presented.)) in relation to red blood cells, as well as the impact of silicon dioxide nanoparticles on biological membranes and liposome models of membranes. The results obtained prove that hemolytic toxicity depends on the concentration of nanoparticles and the incubation period. Silica nanoparticles have a marginal impact on the changes in the osmotic resistance of erythrocytes, except for (Formula presented.), which, similarly to (Formula presented.) and (Formula presented.), changes the shape of erythrocytes from discocytes mainly towards echinocytes. What is more, nanosilica has an impact on the change in fluidity of biological and model membranes. The research gives a new view of the practical possibilities for the use of large-grain nanoparticles in biomedicine.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10400 - Chemical sciences
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
ISSN
1661-6596
e-ISSN
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Volume of the periodical
24
Issue of the periodical within the volume
14
Country of publishing house
CH - SWITZERLAND
Number of pages
20
Pages from-to
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UT code for WoS article
001039466600001
EID of the result in the Scopus database
2-s2.0-85165983789