Trimetallic nanocomposites developed for efficient <i>in vivo</i> bimodal imaging <i>via</i> fluorescence and magnetic resonance

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F46747885%3A24530%2F24%3A00013365" target="_blank" >RIV/46747885:24530/24:00013365 - isvavai.cz</a>

Result on the web

<a href="https://pubs.rsc.org/en/content/articlelanding/2024/tb/d4tb00655k" target="_blank" >https://pubs.rsc.org/en/content/articlelanding/2024/tb/d4tb00655k</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1039/d4tb00655k" target="_blank" >10.1039/d4tb00655k</a>

Result language

angličtina

Original language name

Trimetallic nanocomposites developed for efficient <i>in vivo</i> bimodal imaging <i>via</i> fluorescence and magnetic resonance

Original language description

Despite several attempts, in vivo bimodal imaging still represents a challenge. Generally, it is accepted that dual-modality in imaging can improve sensitivity and spatial resolution, namely, when exploiting fluorescence (FI) and magnetic resonance imaging (MRI), respectively. Here, a newly developed combination of (i) protein-protected luminescent Au-Ag nanoclusters (LGSN) manifesting themselves by fluorescent emission at 705 nm and (ii) superparamagnetic iron oxide nanoparticles (SPION) embedded within the same protein and creating contrast in MR images, has been investigated in phantoms and applied for in vivo bimodal imaging of a mouse as a proof of principle. Unique LGSN-SPION nanocomposites were synthesized in a specific sequential one-pot green preparation procedure and characterized thoroughly using many physicochemical experimental techniques. The influence of LGSN-SPION samples on the viability of healthy cells (RPE-1) was tested using a calcein assay. Despite the presence of Ag (0.12 mg mL(-1)), high content of Au (above 0.75 mg mL(-1)), and moderate concentrations of Fe (0.24 mg mL(-1)), LGSN-SPION samples (containing approx. 15 mg mL(-1) of albumin) were revealed as biocompatible (cell viability above 80%). Simultaneously, these concentration values of all components in the LGSN-SPION nanocomposite were used for achieving both MRI and fluorescence signals in phantoms as well as in a living mouse with sufficiently high resolution. Thus, the LGSN-SPION samples can serve as new efficient bimodal FI and MRI probes for in vivo imaging.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

20903 - Bioproducts (products that are manufactured using biological material as feedstock) biomaterials, bioplastics, biofuels, bioderived bulk and fine chemicals, bio-derived novel materials

Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2024

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

JOURNAL OF MATERIALS CHEMISTRY B

ISSN

2050-750X

e-ISSN

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Volume of the periodical

12

Issue of the periodical within the volume

33

Country of publishing house

GB - UNITED KINGDOM

Number of pages

14

Pages from-to

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UT code for WoS article

001280082700001

EID of the result in the Scopus database

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