Solid lipid nanoparticles for topical antiseptic delivery and release

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F46747885%3A24620%2F18%3A00005690" target="_blank" >RIV/46747885:24620/18:00005690 - isvavai.cz</a>
Alternative codes found
RIV/64577732:_____/18:N0000002
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Solid lipid nanoparticles for topical antiseptic delivery and release
Original language description
Wound healing is a complex process which, in some cases, might be disrupted and slowed down by ongoing infection and inflammation. Over the course of time, these processes, if not treated, may lead to life-threatening states. According to the actual wound treatment trends, attention of researchers is dedicated to in situ drug application and number of novel nanoparticulate dosage forms has been developed. Solid lipid nanoparticles (SLN) belonging to semisolid dosage forms group represent an interesting dosage form easy to produce and offering very good encapsulation efficiency for variety of compounds. In this study, we present gentamicin doped SLN for contaminated wound treatment characteristic by low melting temperature enabling sustained drug release at the body conditions over 72 hours. SLN formed by emulsification technique were evaluated particle size distribution, melting point, antibacterial activity against model strains E. Coli and S. Gallinarum and cytocompatibility to Hacat keratinocytes in vitro.
Czech name
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Czech description
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Project
<a href="/en/project/FV10605" target="_blank" >FV10605: Highly active nanofibrous wound dressing material with barrier function and active drug release</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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