Hemostatic Ability of Thermosensitive Biologically Active Gelatin-Alginate Hydrogels Modified with Humic Acids and Impregnated with Aminocaproic Acid

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F46747885%3A24620%2F24%3A00012568" target="_blank" >RIV/46747885:24620/24:00012568 - isvavai.cz</a>

Result on the web

<a href="https://lifescienceglobal.com/pms/index.php/jrups/article/view/9845" target="_blank" >https://lifescienceglobal.com/pms/index.php/jrups/article/view/9845</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.6000/1929-5995.2024.13.16" target="_blank" >10.6000/1929-5995.2024.13.16</a>

Result language

angličtina

Original language name

Hemostatic Ability of Thermosensitive Biologically Active Gelatin-Alginate Hydrogels Modified with Humic Acids and Impregnated with Aminocaproic Acid

Original language description

The article studies the hemostatic ability of thermosensitive biopolymer hydrogels containing 14% by weight of gelatin and 6.4% by weight of sodium alginate, impregnated with a hemostatic agent aminocaproic acid ~0.2 g/ml, with the addition of humic acids with antioxidant, antibacterial, fungicidal and anti-inflammatory properties.Modification of hydrogels with humic acids slightly increases viscosity, but maintains the gel-sol transition temperature close to the physiological temperature of about 37 °C, which allows them to melt on human skin or inside a wound, ensuring the delivery of aminocaproic acid. SEM images showed that the developed hydrogels have a layered internal morphology, which is improved due to better swelling of the hydrogels contained humic acids, which promotes the dissolution of aminocaproic acid inside the hydrogels and its subsequent rapid delivery to the bleeding site when applying a hydrogel dressing.It has been experimentally established that the concentration of humic acids in hydrogels of no more than 5 wt.% promotes blood clotting due to the entry of aminocaproic acid into it from the hydrogels.The aminocaproic acid delivered at physiological temperature from these hydrogels can shorten the blood clotting time to the lower limit of the normal clotting time range. The clotting time of the hydrogel with 5 wt.% humic acid is only 95 s, which confirms its particularly effective hemostatic ability.

Czech name

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Czech description

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Type

J_SC - Article in a specialist periodical, which is included in the SCOPUS database

CEP classification

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OECD FORD branch

20500 - Materials engineering

Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2024

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Research Updates in Polymer Science

ISSN

1929-5995

e-ISSN

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Volume of the periodical

13

Issue of the periodical within the volume

2

Country of publishing house

CA - CANADA

Number of pages

6

Pages from-to

155-160

UT code for WoS article

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EID of the result in the Scopus database

2-s2.0-85207965415