Mnemonic and behavioral effects of biperiden, an M1-selective antagonist, in the rat
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F47122099%3A_____%2F18%3AN0000005" target="_blank" >RIV/47122099:_____/18:N0000005 - isvavai.cz</a>
Result on the web
<a href="https://link.springer.com/article/10.1007/s00213-018-4899-3" target="_blank" >https://link.springer.com/article/10.1007/s00213-018-4899-3</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s00213-018-4899-3" target="_blank" >10.1007/s00213-018-4899-3</a>
Alternative languages
Result language
angličtina
Original language name
Mnemonic and behavioral effects of biperiden, an M1-selective antagonist, in the rat
Original language description
Rationale: There is a persistent pressing need for valid animal models of cognitive and mnemonic disruptions (such as seen in Alzheimer’s disease and other dementias) usable for preclinical research. Objectives: We have set out to test the validity of administration of biperiden, an M1-acetylcholine receptor antagonist with central selectivity, as a potential tool for generating a fast screening model of cognitive impairment, in outbred Wistar rats. Methods: We used several variants of the Morris water maze task: (1) reversal learning, to assess cognitive flexibility, with probe trials testing memory retention; (2) delayed matching to position (DMP), to evaluate working memory; and (3) “counter-balanced acquisition,” to test for possible anomalies in acquisition learning. We also included a visible platform paradigm to reveal possible sensorimotor and motivational deficits. Results: A significant effect of biperiden on memory acquisition and retention was found in the counter-balanced acquisition and probe trials of the counter-balanced acquisition and reversal tasks. Strikingly, a less pronounced deficit was observed in the DMP. No effects were revealed in the reversal learning task. Conclusions: Based on our results, we do not recommend biperiden as a reliable tool for modeling cognitive impairment.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30103 - Neurosciences (including psychophysiology)
Result continuities
Project
—
Continuities
N - Vyzkumna aktivita podporovana z neverejnych zdroju
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Psychopharmacology
ISSN
1432-2072
e-ISSN
0033-3158
Volume of the periodical
235
Issue of the periodical within the volume
7
Country of publishing house
US - UNITED STATES
Number of pages
13
Pages from-to
213-225
UT code for WoS article
000436110900015
EID of the result in the Scopus database
2-s2.0-85045729041