Challenges in neuropsychological improvement after shunt surgery for idiopathic normal pressure hydrocephalus

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F47122099%3A_____%2F25%3AN0000014" target="_blank" >RIV/47122099:_____/25:N0000014 - isvavai.cz</a>
Alternative codes found
RIV/61383082:_____/25:00001575 RIV/00216208:11110/25:10507257 RIV/00216208:11130/25:10507257 RIV/00064203:_____/25:10507257
Result on the web
<a href="https://www.frontiersin.org/journals/aging-neuroscience/articles/10.3389/fnagi.2025.1725486/full" target="_blank" >https://www.frontiersin.org/journals/aging-neuroscience/articles/10.3389/fnagi.2025.1725486/full</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3389/fnagi.2025.1725486" target="_blank" >10.3389/fnagi.2025.1725486</a>

Result language
angličtina
Original language name
Challenges in neuropsychological improvement after shunt surgery for idiopathic normal pressure hydrocephalus
Original language description
Objectives To evaluate cognitive and mood changes 3 months after shunting for idiopathic normal-pressure hydrocephalus (iNPH), and compare postoperative outcomes with matched healthy controls across cognitive domains. Methods Thirty-three iNPH patients underwent neuropsychological testing preoperatively and at 3 months; 71 age-, sex-, and education-matched controls were assessed once. Tests were grouped into six cognitive domains.Results Shunting yielded significant gains in Verbal Memory and Psychomotor Pace; Executive Functions improved selectively. Non-Verbal Memory, Language, and Visuospatial Abilities showed no postoperative change. Depressive symptoms decreased significantly. However, at 3 months patients still performed worse than controls on all tests (all p < 0.001). Conclusion Shunt surgery produces measurable yet domain-limited cognitive benefits in iNPH at 3 months, particularly in verbal learning and processing speed, alongside mood improvement. Performance remains below healthy norms, indicating partial recovery. Larger, prospective cohorts and longer follow-up are needed to determine durability, breadth of cognitive change, and predictors of response.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
50100 - Psychology and cognitive sciences

Project
<a href="/en/project/NU23-04-00551" target="_blank" >NU23-04-00551: A Complex Multi-layer Diagnostic Battery for NPH</a><br>
Continuities
N - Vyzkumna aktivita podporovana z neverejnych zdroju

Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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