Morphology of the Immune Cells in the Wall of the Human Uterine Tube and Their Possible Impact on Reproduction - Uterine Tube as a Possible Immune Privileged Organ

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F49777513%3A23310%2F24%3A43971564" target="_blank" >RIV/49777513:23310/24:43971564 - isvavai.cz</a>

Result on the web

<a href="http://doi.org/10.3389/fcell.2024.1325565" target="_blank" >http://doi.org/10.3389/fcell.2024.1325565</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3389/fcell.2024.1325565" target="_blank" >10.3389/fcell.2024.1325565</a>

Result language

angličtina

Original language name

Morphology of the Immune Cells in the Wall of the Human Uterine Tube and Their Possible Impact on Reproduction - Uterine Tube as a Possible Immune Privileged Organ

Original language description

The uterine tube, as well as other parts of the upper female reproductive system, is immunologically unique in its requirements for tolerance to allogenic sperm and semi-allogenic embryos, yet responds to an array of sexually transmitted pathogens. To understand this dichotomy, there is a need to understand the functional morphology of immune cells in the wall of the uterine tube. Thus, we reviewed scientific literature regarding immune cells and the human uterine tube by using the scientific databases. The human uterine tube has a diverse population of immunocompetent cells representing both the innate and adaptive immune systems. We describe in detail the possible roles of cells of the mononuclear phagocyte system (macrophages and dendritic cells), T and B lymphocytes, NK cells, neutrophils and mast cells in association with the reproductive functions of uterine tubes. We are also discussing about the possible &quot;immune privilege&quot; of the uterine tube, as another mechanism to tolerate sperm and embryo without eliciting an inflammatory immune response. In uterine tube is not present an anatomical blood-tissue barrier between antigens and circulation. However, the immune cells of the uterine tube probably represent a type of &quot;immunological barrier&quot;, which probably includes the uterine tube among the immunologically privileged organs. Understanding how immune cells in the female reproductive tract play roles in reproduction is essential to understand not only the mechanisms of gamete transport and fertilization as well as embryo transport through the uterine tube, but also in improving results from assisted reproduction.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30214 - Obstetrics and gynaecology

Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2024

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Frontiers in Cell and Developmental Biology

ISSN

2296-634X

e-ISSN

2296-634X

Volume of the periodical

12

Issue of the periodical within the volume

7 March 2024

Country of publishing house

CH - SWITZERLAND

Number of pages

9

Pages from-to

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UT code for WoS article

001189521500001

EID of the result in the Scopus database

2-s2.0-85188170935