The Trail Walking Test to predict probable mild cognitive impairment in older adults

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F49777513%3A23310%2F24%3A43972781" target="_blank" >RIV/49777513:23310/24:43972781 - isvavai.cz</a>

Result on the web

<a href="https://doi.org/10.48095/cccsnn2024239" target="_blank" >https://doi.org/10.48095/cccsnn2024239</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.48095/cccsnn2024239" target="_blank" >10.48095/cccsnn2024239</a>

Result language

angličtina

Original language name

The Trail Walking Test to predict probable mild cognitive impairment in older adults

Original language description

Background: Early detection of mild cognitive impairment (MCI) as a risk factor for dementia using valid screening tools can present an opportunity for timely intervention to slow the progression of cognitive decline in older adults. Aim: The aim of this study was to evaluate the Trail Walking Test (TWT) that includes a dual task to predict probable MCI (pMCI) in older adults and to evaluate its usability as a screening tool. Methods: The study was conducted on a sample of 61 subjects categorized using the Montreal Cognitive Assessment (MoCA) into three groups: older adults with intact cognitive ability (ICA, MoCA &gt; 25); older adults with pMCI (MoCA ≤ 25); and “healthy young adults (HYA)”. All participants completed the Trail Making Test (TMT) and three variants of the TWT with increasing complexity. Area under the receiver operating curve (AUC), sensitivity, specifi city and Youden indices were used to evaluate the capacity of each test to predict pMCI in older adults. Internal validation was performed to calculate AUCs corrected for optimism (AUCVAL). Results: The pMCI group performed signifi cantly worse in all evaluated variations of the TMT and TWT than the ICA and HYA groups (P &lt; 0.001). We found that all versions of the TMT (e. g., TMT-A and TMT-B) and TWT tests (e. g., TWT-1, 2, 3) have very good ability to discriminate between people with pMCI and all controls (e. g., ICA and HYA combined) with AUCs ranging from 0.81 to 0.876, generally increasing with increasing complexity of the dual task. Best performance was achieved when only HYA were used as a control group (AUCs: 0.894–0.975). The validity of these tools to predict pMCI remained very good after corrections using bootstrapping (AUCs: 0.829–0.839). While TWT-2 showed more benefi ts over TWT-1, the added value of TWT-3 over TWT-2 has been limited in this study. Conclusions: The dual component TWT is a valid screening tool for pMCI in older adults. Its use may improve early detection of pMCI in clinical and non-clinical settings. While increasing complexity of the test increases its predicting performance, based on our fi ndings there seems to be a cutoff beyond which the added value of more complex dual tasks diminishes.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30227 - Geriatrics and gerontology

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2024

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Česká a slovenská neurologie a neurochirurgie

ISSN

1210-7859

e-ISSN

1802-4041

Volume of the periodical

87

Issue of the periodical within the volume

4

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

9

Pages from-to

239-247

UT code for WoS article

001329075900001

EID of the result in the Scopus database

2-s2.0-85206883517