Conformation study of a-ring in 19β,28-epoxy-2-fluoro-18α-oleananes

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F49777513%3A23420%2F06%3A00000003" target="_blank" >RIV/49777513:23420/06:00000003 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Conformation study of a-ring in 19β,28-epoxy-2-fluoro-18α-oleananes

Original language description

A series of 2-fluoro-substituted 19ß,28-epoxy-18&#945;-oleanane triterpenoids was prepared. Detailed NMR analysis (1H, 13C, 19F) was used for independent determination of the configuration of substituents. Conformation of the A-ring was derived from coupling constants J(H,H), J(F,H), J(F,C) and NOE-contacts observed in 2D-H,H-NOESY spectra. It was found that A-ring in all 2&#945;-fluoro derivatives and 2ß-fluoro-3ß-OR derivatives and adopts chair-form, while in 2ß-fluoro ketone a boat-form is preferred.The chair&#8211;boat equilibrium of A-ring was found in 2ß-fluoro-3.-OR derivatives.

Czech name

Konformační studie a-kruhu 19β,28-epoxy-2-fluoro-18α-oleananů.

Czech description

Byla připravena řada triterpenoidních 2-flouro substituentů 19ß,28-epoxy-18beta-oleananu. Podrobnou NMR analýzou byla určena konfigurace substituentů.

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CC - Organic chemistry

OECD FORD branch

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Project

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Continuities

S - Specificky vyzkum na vysokych skolach

Publication year

2006

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Collection of Czechoslovak Chemical Communications

ISSN

0010-0765

e-ISSN

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Volume of the periodical

71

Issue of the periodical within the volume

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Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

19

Pages from-to

368

UT code for WoS article

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EID of the result in the Scopus database

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