High-Dose Nitrate Supplementation Attenuates the Increased Blood Pressure Responses to Isometric Blood Flow Restriction Exercise in Healthy Males

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F49777513%3A23420%2F22%3A43965739" target="_blank" >RIV/49777513:23420/22:43965739 - isvavai.cz</a>

Result on the web

<a href="https://www.mdpi.com/2072-6643/14/17/3645" target="_blank" >https://www.mdpi.com/2072-6643/14/17/3645</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/nu14173645" target="_blank" >10.3390/nu14173645</a>

Result language

angličtina

Original language name

High-Dose Nitrate Supplementation Attenuates the Increased Blood Pressure Responses to Isometric Blood Flow Restriction Exercise in Healthy Males

Original language description

The effect of nitrate (NO3 -) supplementation on blood pressure (BP) responses during large muscle mass isometric and ischaemic exercise in healthy young adults is unclear. The aim of the present study was to assess the effect of 5-day supplementation of NO3- on BP responses during a short isometric contraction and a sustained ischaemic contraction. In a randomised, doubleblinded, crossover design, 14 healthy active young adults underwent BP measurements after 5 days of either NO3- (NIT) or placebo (PLA) supplementation. Beat-by-beat BP was measured at preand post-exercise rest, and during a short (20 s) isometric contraction at 25% maximal strength and throughout a sustained ischaemic contraction. Plasma nitrite (NO2-) concentration increased significantly after NO3- supplementation compared to placebo. Systolic BP was significantly lower at pre- (p = 0.051) and post-exercise rest (p = 0.006), during a short isometric contraction (p = 0.030), and throughout a sustained ischaemic contraction (p = 0.040) after NO3- supplementation. Mean arterial pressure was significantly lower at pre- (p = 0.004) and post-exercise rest (p = 0.043), during a short isometric contraction (p = 0.041), and throughout a austained ischaemic contraction (p = 0.021) after NO3- supplementation. Diastolic BP was lower at pre-exercise rest (p = 0.032), but not at post-exercise rest, during a short isometric contraction, and during a sustained ischaemic contraction (all p &gt; 0.05). Five days of NO3- supplementation elevated plasma NO2- concentration and reduced BP during a short isometric contraction and a sustained ischaemic contraction in healthy adults. These observations indicate that multiple-day nitrate supplementation can decrease BP at rest and attenuate the increased BP response during isometric exercise. These findings support that NO3- supplementation is an effective nutritional intervention in reducing SBP and MAP in healthy young males during submaximal exercise.

Czech name

—

Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30308 - Nutrition, Dietetics

Project

<a href="/en/project/EF18_054%2F0014627" target="_blank" >EF18_054/0014627: Development of capacities and environment for boosting the international, intersectoral and interdisciplinary cooperation at UWB</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2022

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Nutrients

ISSN

2072-6643

e-ISSN

2072-6643

Volume of the periodical

14

Issue of the periodical within the volume

17

Country of publishing house

CH - SWITZERLAND

Number of pages

11

Pages from-to

"Nestránkováno"

UT code for WoS article

000851637000001

EID of the result in the Scopus database

2-s2.0-85137564061