Distribution of orientation of smooth muscle bundles does not change along human great and small varicose veins

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F49777513%3A23520%2F14%3A43922070" target="_blank" >RIV/49777513:23520/14:43922070 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1016/j.aanat.2013.10.005" target="_blank" >http://dx.doi.org/10.1016/j.aanat.2013.10.005</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.aanat.2013.10.005" target="_blank" >10.1016/j.aanat.2013.10.005</a>

Result language

angličtina

Original language name

Distribution of orientation of smooth muscle bundles does not change along human great and small varicose veins

Original language description

Wall remodeling in varicose veins is associated with hypertrophy of subendothelial tissue, increase in inner diameter, wrinkling and invagination of the endothelial layer. Due to structural alterations of the wall, the smooth muscle cells (SMCs) change their original circular and longitudinal orientations. Our aim was to quantify the volume fraction of circularly, longitudinally and obliquely oriented SMCs within both the inner and outer half of the wall of 11 great saphenous varicose veins and five small saphenous varicose veins. Using stereological methods applied on cross-sections of the vessels regularly gained each 5 cm along the vessel we determined the wall thickness (846 ± 319 μm, mean ± standard deviation), the volume fraction of circular SMCs in the inner (0.19 ± 0.13) and outer (0.06 ± 0.06) layers, the volume fraction of longitudinal SMCs in the inner (0.06 ± 0.05) and outer (0.05 ± 0.04) layers, the volume fraction of oblique SMCs in the inner (0.15 ± 0.08) and outer (0.09 ± 0.08) layers, and the total volume fraction of SMCs in the inner (0.4 ± 0.1) and outer (0.21 ± 0.09) layers. The volume fraction of SMCs with circular and oblique but not with longitudinal orientation was greater in the inner layer compared to the outer layer. The SMC orientation distribution was uniform along the varicose saphenous veins. With increasing wall thickness, the volume fraction of longitudinal and oblique SMC bundles increased in both layers at the expansion of circular SMC bundles. The main differences in the orientation of the SMCs in the inner and outer wall layers should be taken into account when computational modeling of varicose saphenous veins is attempted.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

20503 - Textiles; including synthetic dyes, colours, fibres (nanoscale materials to be 2.10; biomaterials to be 2.9)

Project

<a href="/en/project/ED1.1.00%2F02.0090" target="_blank" >ED1.1.00/02.0090: NTIS - New Technologies for Information Society</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2014

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

ANNALS OF ANATOMY-ANATOMISCHER ANZEIGER

ISSN

0940-9602

e-ISSN

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Volume of the periodical

196

Issue of the periodical within the volume

2-3

Country of publishing house

NL - THE KINGDOM OF THE NETHERLANDS

Number of pages

8

Pages from-to

67-74

UT code for WoS article

000337872900001

EID of the result in the Scopus database

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