A mathematical model of the carp heart ventricle during the cardiac cycle
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F49777513%3A23520%2F15%3A43925204" target="_blank" >RIV/49777513:23520/15:43925204 - isvavai.cz</a>
Alternative codes found
RIV/67985823:_____/15:00444381 RIV/00216208:11140/15:10294777 RIV/49777513:23640/15:43925204
Result on the web
<a href="http://dx.doi.org/10.1016/j.jtbi.2015.03.014" target="_blank" >http://dx.doi.org/10.1016/j.jtbi.2015.03.014</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.jtbi.2015.03.014" target="_blank" >10.1016/j.jtbi.2015.03.014</a>
Alternative languages
Result language
angličtina
Original language name
A mathematical model of the carp heart ventricle during the cardiac cycle
Original language description
The poikilothermic heart has been suggested as a model for studying some of the mechanisms of early postnatal mammalian heart adaptations. We assessed morphological parameters of the carp heart (Cyprinus carpio L.) with diastolic dimensions: heart radius (5.73 mm), thickness of the compact (0.50 mm) and spongy myocardium (4.34 mm), in two conditions (systole, diastole): volume fraction of the compact myocardium (20.7% systole, 19.6% diastole), spongy myocardium (58.9% systole, 62.8% diastole), trabeculae (37.8% systole, 28.6% diastole), and cavities (41.5% systole, 51.9% diastole) within the ventricle; volume fraction of the trabeculae (64.1% systole, 45.5% diastole) and sinuses (35.9% systole, 54.5% diastole) within the spongy myocardium; ratio between the volume of compact and spongy myocardium (0.35 systole, 0.31 diastole); ratio between compact myocardium and trabeculae (0.55 systole, 0.69 diastole); and surface density of the trabeculae (0.095 ?m-1 systole, 0.147 ?m-1 diastole). We created a mathematical model of the carp heart based on actual morphometric data to simulate how the compact/spongy myocardium ratio, the permeability of the spongy myocardium, and sinus-trabeculae volume fractions within the spongy myocardium influence stroke volume, stroke work, ejection fraction and p-V diagram. Increasing permeability led to increasing and then decreasing stroke volume and work, and increasing ejection fraction. An increased amount of spongy myocardium led to an increased stroke volume, work, and ejection fraction. Varying sinus-trabeculae volume fractions within the spongy myocardium showed that an increased sinus volume fraction led to an increased stroke volume and work, and a decreased ejection fraction.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EA - Morphology and cytology
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
JOURNAL OF THEORETICAL BIOLOGY
ISSN
0022-5193
e-ISSN
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Volume of the periodical
373
Issue of the periodical within the volume
May
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
14
Pages from-to
12-25
UT code for WoS article
000354002800002
EID of the result in the Scopus database
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