Modeling of the contrast-enhanced perfusion test in liver based on the multi-compartment flow in porous media

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F49777513%3A23520%2F18%3A43950069" target="_blank" >RIV/49777513:23520/18:43950069 - isvavai.cz</a>

Result on the web

<a href="https://doi.org/10.1007/s00285-018-1209-y" target="_blank" >https://doi.org/10.1007/s00285-018-1209-y</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s00285-018-1209-y" target="_blank" >10.1007/s00285-018-1209-y</a>

Result language

angličtina

Original language name

Modeling of the contrast-enhanced perfusion test in liver based on the multi-compartment flow in porous media

Original language description

The paper deals with modeling the liver perfusion intended to improve quantitative analysis of the tissue scans provided by the contrast-enhanced computed tomography (CT). For this purpose, we developed a model of dynamic transport of the contrast fluid through the hierarchies of the perfusion trees. Conceptually, computed time-space distributions of the so-called tissue density can be compared with the measured data obtained from CT; such a modeling feedback can be used for model parameter identification. The blood flow is characterized at several scales for which different models are used. Flows in upper hierarchies represented by larger branching vessels are described using simple 1D models based on the Bernoulli equation extended by correction terms to respect the local pressure losses. To describe flows in smaller vessels and in the tissue parenchyma, we propose a 3D continuum model of porous medium defined in terms of hierarchically matched compartments characterized by hydraulic permeabilities. The 1D models corresponding to the portal and hepatic veins are coupled with the 3D model through point sources, or sinks. The contrast fluid saturation is governed by transport equations adapted for the 1D and 3D flow models. The complex perfusion model has been implemented using the finite element and finite volume methods. We report numerical examples computed for anatomically relevant geometries of the liver organ and of the principal vascular trees. The simulated tissue density corresponding to the CT examination output reflects a pathology modeled as a localized permeability deficiency.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

20302 - Applied mechanics

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2018

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Mathematical Biology

ISSN

0303-6812

e-ISSN

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Volume of the periodical

77

Issue of the periodical within the volume

2

Country of publishing house

DE - GERMANY

Number of pages

34

Pages from-to

421-454

UT code for WoS article

000439442300005

EID of the result in the Scopus database

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