All

What are you looking for?

All
Projects
Results
Organizations

Quick search

  • Projects supported by TA ČR
  • Excellent projects
  • Projects with the highest public support
  • Current projects

Smart search

  • That is how I find a specific +word
  • That is how I leave the -word out of the results
  • “That is how I can find the whole phrase”

A Novel Approach to Multi-Compartmental Model Implementation to Achieve Metabolic Model Identifiability on Patient's CGM Data

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F49777513%3A23520%2F22%3A43966174" target="_blank" >RIV/49777513:23520/22:43966174 - isvavai.cz</a>

  • Result on the web

    <a href="https://www.sciencedirect.com/science/article/pii/S1877050922015848" target="_blank" >https://www.sciencedirect.com/science/article/pii/S1877050922015848</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1016/j.procs.2022.10.127" target="_blank" >10.1016/j.procs.2022.10.127</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    A Novel Approach to Multi-Compartmental Model Implementation to Achieve Metabolic Model Identifiability on Patient's CGM Data

  • Original language description

    Diabetes is a widespread civilization disease. When developing a new treatment method, in-silico benefits the development process by reducing the need for in-vivo subjects. In-silico evaluation requires a reliable metabolic model, often created as a multi-compartmental model. A common approach to implementing a multi-compartmental model is to use a system of ordinary differential equations. This approach utilises exponential transfer functions to transfer substances among the compartments. Using other than an exponential function is complex. Therefore, we propose a novel approach based on a direct, numeric integration of separated compartments, which can be further divided into individual depots. This enables to model substance transfer as a separate process with non-exponential characteristics, e.g.; when modelling carbohydrate absorption from the gut. As another benefit, the approach obeys the law of mass conservation on both the computational and architectural levels. This is a key feature when identifying a model on data, that are not measured within a controlled, isolated environment. Moreover, we actually transform the set of equations, i.e.; computer-code functions, into a component model to reduce the total maintenance costs – readability, testing, verification and deployment. We demonstrate the proposed approach by converting the Samadi model to it and enhancing it with a non-exponential transfer function.

  • Czech name

  • Czech description

Classification

  • Type

    D - Article in proceedings

  • CEP classification

  • OECD FORD branch

    10201 - Computer sciences, information science, bioinformathics (hardware development to be 2.2, social aspect to be 5.8)

Result continuities

  • Project

    <a href="/en/project/EF19_073%2F0016931" target="_blank" >EF19_073/0016931: Improving the quality of the internal grant structure at UWB</a><br>

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2022

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Article name in the collection

    Procedia Computer Science

  • ISBN

  • ISSN

    1877-0509

  • e-ISSN

  • Number of pages

    8

  • Pages from-to

    116-123

  • Publisher name

    Elsevier

  • Place of publication

  • Event location

    Leuven, Belgium

  • Event date

    Oct 26, 2022

  • Type of event by nationality

    EUR - Evropská akce

  • UT code for WoS article