Titanium-based porous materials with nanostructured bioactive surface for enhanced osseointegration

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F49777513%3A23640%2F19%3A43958155" target="_blank" >RIV/49777513:23640/19:43958155 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Titanium-based porous materials with nanostructured bioactive surface for enhanced osseointegration

Original language description

Despite the great progress that has been achieved in orthopedics biomaterials, fixation of implants to the bone host remains a problem. Mismatch of Young’s moduli of the biomaterials and the surrounding bone has been identified as a major reason for implant loosening following stress shielding of bone. However, the implanted material must be strong enough and durable to withstand the physiological loads placed upon it over the years. A suitable balance between strength and stiffness has to be found to the best match of bone behaviour. Titanium and its alloy (Ti6Al4V) have elastic moduli less than 50% of that commonly used Co–Cr implants so that their use helps reduce the extent of stress shielding. One consideration to achieve this has been the development of materials that exhibit substantial surface or total bulk porosity in medical applications. Moreover, bioactive surface chemical composition and suitable surface morphology on micro- and nanoscale level is necessary for efficient osseointegration. Here we report on novel concept of hierarchically functionalized titanium based biomaterial consists in (i) laser induced surface porosity, (ii) micro/messoporous bioactive glass fillers, (iii) chemical activation and/or ablative deposition of bioactive CaTiO3 nanoparticles. Prepared biomaterials were analyzed by SEM/EDX, XRD, Raman spectroscopy and test in terms of cell cultivation in order to reveal biocompatibility, cell viability and osseointegration ability.

Czech name

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Czech description

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Type

O - Miscellaneous

CEP classification

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OECD FORD branch

10403 - Physical chemistry

Project

<a href="/en/project/LO1402" target="_blank" >LO1402: CENTEM+</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2019

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů