Self-assembly of hydrophobically modified hyaluronic acid
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F49777513%3A23640%2F21%3A43962185" target="_blank" >RIV/49777513:23640/21:43962185 - isvavai.cz</a>
Alternative codes found
RIV/00216305:26620/21:PU139345
Result on the web
<a href="https://doi.org/10.1016/j.apsusc.2021.149161" target="_blank" >https://doi.org/10.1016/j.apsusc.2021.149161</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.apsusc.2021.149161" target="_blank" >10.1016/j.apsusc.2021.149161</a>
Alternative languages
Result language
angličtina
Original language name
Self-assembly of hydrophobically modified hyaluronic acid
Original language description
The understanding how physicochemical properties of amphiphilic molecules influence the self-assembly process is crucial to control their final nanostructure. Furthermore, the relationship between the supramolecular structure and functional properties is of utmost importance for effective design towards specific applications. The hydrophobically modified hyaluronic acid was investigated as a representative of semi-flexible amphiphilic polyelectrolyte with the tremendous biomedical potential. The essential physicochemical characteristics were extracted from the interplay of multiple techniques such as rheology, fluorescence, dynamic light scattering, surface tension, and small-angle X-ray scattering. The correlation of used techniques allowed us to determine the size of hydrophobic domains and showed that aggregate size decrease with increasing chain flexibility. Furthermore, the ratio between the size of aggregates and hydrophobic domains was found to be crucial for curcumin loading efficiency and in vitro skin penetration. Moreover, critical aggregation concentration was determined using various techniques. However, aggregates were found below these concentrations. The rheological characterization identified different dynamical regimes that can define the preparation and application concentration range. The acquired supramolecular structureproperty function provides valuable information for the design of self-assembled nanostructures.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10403 - Physical chemistry
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
APPLIED SURFACE SCIENCE
ISSN
0169-4332
e-ISSN
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Volume of the periodical
546
Issue of the periodical within the volume
APR 30 2021
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
8
Pages from-to
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UT code for WoS article
000620364900006
EID of the result in the Scopus database
2-s2.0-85100265552