Smart injectable hydrogels for periodontal regeneration: Recent advancements in biomaterials and biofabrication strategies
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F49777513%3A23640%2F25%3A43976535" target="_blank" >RIV/49777513:23640/25:43976535 - isvavai.cz</a>
Result on the web
<a href="https://doi.org/10.1016/j.mtbio.2025.101855" target="_blank" >https://doi.org/10.1016/j.mtbio.2025.101855</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.mtbio.2025.101855" target="_blank" >10.1016/j.mtbio.2025.101855</a>
Alternative languages
Result language
angličtina
Original language name
Smart injectable hydrogels for periodontal regeneration: Recent advancements in biomaterials and biofabrication strategies
Original language description
Periodontitis is a globally prevalent chronic inflammatory disease that leads to periodontal pocket formation and eventually destroys tooth-supporting structures. Hence, the drastic increase in dental implants for periodontitis has become a severe clinical issue. Injectable hydrogel based on extracellular matrix (ECM) is highly biocompatible and tissue-regenerative with tailor-made mechanical properties and high payload capacity for in situ delivery of bioactive molecules to treat periodontitis. This therapeutic tool not only enhances the drug release efficiency and treatment efficacy but also reduces operation time. Nevertheless, it remains challenging to optimize the mechanical properties and intelligent control drug release rate of injectable hydrogels to achieve the highest therapeutic outcome. Literature precedent has shown the modulation of polymer backbones (synthetic polymers, natural polysaccharides, and proteins), crosslinking strategies, other bioactive constituents, and potentially the incorporation of nanomaterials that overall improve the desirable physiochemical and biological performances as well as biodegradability. In this review, we summarize the recent advances in the development, design, and material characterizations of common injectable hydrogels. Furthermore, we highlight cutting-edge representative examples of polysaccharide-, protein- and nanocomposite-based hydrogels that mediate regenerative factors and anti-inflammatory drugs for periodontal regeneration. Finally, we express our perspectives on potential challenges and future development of multifunctional injectable hydrogels for periodontitis.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30404 - Biomaterials (as related to medical implants, devices, sensors)
Result continuities
Project
<a href="/en/project/EH22_008%2F0004634" target="_blank" >EH22_008/0004634: Mechanical engineering of biological and bio-inspired systems</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
MATERIALS TODAY BIO
ISSN
2590-0064
e-ISSN
2590-0064
Volume of the periodical
32
Issue of the periodical within the volume
JUN 2025
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
25
Pages from-to
nestránkováno
UT code for WoS article
001502219100001
EID of the result in the Scopus database
2-s2.0-105004887680