Genistein effects on haematoimmune cells in a newly developed alternative toxicological model

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60076658%3A12110%2F12%3A43883280" target="_blank" >RIV/60076658:12110/12:43883280 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1016/j.etp.2010.10.006" target="_blank" >http://dx.doi.org/10.1016/j.etp.2010.10.006</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.etp.2010.10.006" target="_blank" >10.1016/j.etp.2010.10.006</a>

Result language
angličtina
Original language name
Genistein effects on haematoimmune cells in a newly developed alternative toxicological model
Original language description
Unexpected, sometimes opposite effects of dietary isoflavonic phytoestrogens on immunity may suggest that classical mammalian toxicological assays are not entirely suitable for preclinical safety tests of these compounds. We evaluated a new alternative model of haemocytes of Egyptian cotton worm in vivo following genistein administration. Genistein induced significant changes in nucleolar morphology of haemocytes but did not influence their counts and nucleolar indices. The results indicate that genistein does not affect proliferation and differentiation of normal cells but potentiates their immunocompetence. Egyptian cotton worm larvae seem to be the new alternative biomodel for immunological screening.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FR - Pharmacology and apothecary chemistry
OECD FORD branch
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Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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