Aluminofluoride Complexes: Phosphate Analogues and a Hidden Hazard

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60076658%3A12110%2F12%3A43883780" target="_blank" >RIV/60076658:12110/12:43883780 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Aluminofluoride Complexes: Phosphate Analogues and a Hidden Hazard
Original language description
There is a burgeoning body of evidence that aluminum can be implicated as an etiological factor of several neuropathological events. The molecular mechanisms underlying aluminum toxicity are still poorly understood. Reflecting on many studies, we suggesta new view on the toxicity of aluminum in a link with fluoride. Soluble aluminofluoride complexes - fluoroaluminate (AlFx) are formed in water solutions containing fluoride and traces of aluminum. These complexes are able to simulate phosphate groups inmany biochemical reactions. AlFx are used in many laboratory investigations of guanine nucleotide binding proteins (G proteins). They affect various enzyme activities and cell signaling cascades. The hidden danger of a long-term synergistic action of aluminum and fluoride is not fully recognized at this point. We suggest that aluminum and fluoride can exacerbate the pathological and clinical problems, namely by interfering with a great number of G-protein-dependent cellular mechanisms,
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CA - Inorganic chemistry
OECD FORD branch
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Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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