Genetic polymorphism of Myf-5 and myostatin in Charolais breed

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60076658%3A12220%2F09%3A00010754" target="_blank" >RIV/60076658:12220/09:00010754 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Genetic polymorphism of Myf-5 and myostatin in Charolais breed
Original language description
The production of animals with superior muscle structure is of great importance to food animal agriculture. Muscle Regulatory Factors regulate skeletal muscle fiber development and postnatal hypertrophic growth. The genes of the muscle regulatory factors? gene family, consisting of 4 structurally related transcription factors - myogenin, MyoD1, myf-5, and MRF4. Myf-5 is one of four transcription factors belonging to the MyoD family that play key roles in skeletal muscle determination and differentiation. Myostatin acts as a negative regulator of muscle growth. Mutations in the gene are responsible for the double muscling phenotype in several European cattle breeds. We analyzed Charolais breed from Hungary. We used a PCR-RFLP method for genotyping Myf-5gene and myostatin Q204X mutation. These genes play an important role in the muscular development regulation. The heterozygous genotype was mostly representated in Myf-5 gene. As for myostatin, it was identified 10 heterozygotes in Q204X
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Publication year
2009
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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