Effect of Streptococcus uberis on Gamma Delta T Cell Phenotype in Bovine Mammary Gland

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60076658%3A12220%2F21%3A43903346" target="_blank" >RIV/60076658:12220/21:43903346 - isvavai.cz</a>

Result on the web

<a href="https://www.mdpi.com/2076-2615/11/12/3594" target="_blank" >https://www.mdpi.com/2076-2615/11/12/3594</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/ani11123594" target="_blank" >10.3390/ani11123594</a>

Result language

angličtina

Original language name

Effect of Streptococcus uberis on Gamma Delta T Cell Phenotype in Bovine Mammary Gland

Original language description

Bovine mastitis (inflammation of the mammary gland) is still an important problem for dairy farmers. This disease causes great financial losses across the world. The common method of treating mastitis is through the use of antibiotics. Antibiotic treatment should be minimized because of increasing antibiotic resistance. Streptococcus uberis (S. uberis) is one of the most important pathogens that causes bovine mastitis. This bacterium is able to hide and survive inside of epithelial cells. In this situation, antibiotic treatment is not efficient. Therefore, it is necessary to study the pathogenesis of mastitis that is caused by S. uberis to better understand how to treat this disease. In this study, we investigated a special type of lymphocytes-gamma delta T cells. The results of our study show that those cells may play a role in terminating inflammation in the mammary glands of cattle. In this study, we focused analyzing gamma delta T cells during bovine mammary gland inflammation induced by Streptococcus uberis. A mammary gland cell suspension was obtained using lavage 24, 48, 72, and 168 h after intramammary-induced infection. The proportion of lymphocytes increased during the entire week in which inflammation was present. The gamma delta T cells were also elevated during inflammation, reaching their peak at 72 h following induced inflammation. The percentage of apoptotic lymphocytes continually increased, with the highest proportion occurring 168 h after S. uberis infection. The results show that gamma delta T cells may be involved in the resolution of inflammation in bovine mammary glands, with the apoptosis of those cells potentially playing an important role.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

40201 - Animal and dairy science; (Animal biotechnology to be 4.4)

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2021

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Animal

ISSN

1751-7311

e-ISSN

—

Volume of the periodical

11

Issue of the periodical within the volume

12

Country of publishing house

GB - UNITED KINGDOM

Number of pages

8

Pages from-to

3594

UT code for WoS article

000735280800001

EID of the result in the Scopus database

2-s2.0-85121296766