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Co-inoculation of Borrelia afzelii with tick salivary gland extract influences distribution of immunocompetent cells in the skin and lymph nodes of mice

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60076658%3A12310%2F05%3A00006339" target="_blank" >RIV/60076658:12310/05:00006339 - isvavai.cz</a>

  • Alternative codes found

    RIV/60077409:_____/05:00048627

  • Result on the web

  • DOI - Digital Object Identifier

Alternative languages

  • Result language

    angličtina

  • Original language name

    Co-inoculation of Borrelia afzelii with tick salivary gland extract influences distribution of immunocompetent cells in the skin and lymph nodes of mice

  • Original language description

    The impact of Ixodes ricinus salivary gland extract (SGE) on inflammatory changes in the skin and draining lymph nodes of mice, elicited by the infection with the important human pathogen, B. afzeIii, was determined using flow cytometry. SGE injected together with spirochetes reduced the numbers of leukocytes and gamma delta-T lymphocytes in infected epidermis at early time-points post infection. In draining lymph nodes, the anti-inflammatory effect of SGE was manifested by the decrease of total cell count compared with that in mice treated with inactivated SGE. Changes in subpopulations of immunocompetent cells apparently reflected the effect of SGE on the proliferation of spirochetes in the host. The significance of tick saliva anti-inflammatory effect for saliva activated transmission of B. afzelii is shown.

  • Czech name

    Extrakt ze slinných žlaz klíštěte ovlivňuje distribuci imunokompetentních buněk v kůži a lymfatických uzlinách myší infikovaných Borrelia afzelii

  • Czech description

    Byl studován vliv extraktu ze slinných žlaz (SGE) klíštěte ixodes ricinus na distribuci imunokompetentních buněk v kůži a lymfatických uzlinách myší infikovaných Borrelia afzelii. SGE významně snižovalo množství gama delta T lymfocytů v kůži infikovanýchmyší. Také v lymfatických uzlinách došlo ke snížení množství leukocytů ve skupinách ovlivněných SGE oproti myším, kterým bylo aplikováno inaktivované SGE. Výsledky podporují hypotézu o slinami aktivovaném přenosu borelií na savčího hostitele.

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    EC - Immunology

  • OECD FORD branch

Result continuities

  • Project

    <a href="/en/project/GA524%2F02%2F0901" target="_blank" >GA524/02/0901: Effect of tick saliva on the transmission of Borrelia burgdorferi</a><br>

  • Continuities

    Z - Vyzkumny zamer (s odkazem do CEZ)

Others

  • Publication year

    2005

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Folia Microbiologica

  • ISSN

    0015-5632

  • e-ISSN

  • Volume of the periodical

    50

  • Issue of the periodical within the volume

    5

  • Country of publishing house

    CZ - CZECH REPUBLIC

  • Number of pages

    7

  • Pages from-to

    457-463

  • UT code for WoS article

  • EID of the result in the Scopus database