Proenzyme therapy of sarcoma S-180 and melanoma B16-F10
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60076658%3A12310%2F14%3A43887094" target="_blank" >RIV/60076658:12310/14:43887094 - isvavai.cz</a>
Result on the web
<a href="http://ac.els-cdn.com/S1214021X13000045/1-s2.0-S1214021X13000045-main.pdf?_tid=0616d5d6-a178-11e4-ad19-00000aacb360&acdnat=1421849939_9c14e559b97dc64ea748296e84131bd6" target="_blank" >http://ac.els-cdn.com/S1214021X13000045/1-s2.0-S1214021X13000045-main.pdf?_tid=0616d5d6-a178-11e4-ad19-00000aacb360&acdnat=1421849939_9c14e559b97dc64ea748296e84131bd6</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.jab.2012.11.001" target="_blank" >10.1016/j.jab.2012.11.001</a>
Alternative languages
Result language
angličtina
Original language name
Proenzyme therapy of sarcoma S-180 and melanoma B16-F10
Original language description
The aim of this study was to evaluate the effectiveness of individual (inactive) proenzymes and mixtures thereof in cancer treatment and to compare this treatment with more frequently used therapy based on active proteases. Experiments focused on explanation of possible mechanisms of proenzyme action against tumours are included. Proenzyme therapy of sarcoma S-180 significantly reduced tumour growth and prolonged survival of mice. The effect of trypsinogen and chymotrypsinogen was synergistic. Proenzymetherapy of melanoma B16-F10 bearing mice reduced both tumour growth and prevalence of metastases. Active enzyme based therapy of melanoma B16-F10 was less effective. Severe combined immunodeficiency (SCID) mice bearing sarcoma S-180 did not respond to the proenzyme therapy, indicating that the effect of this therapy is dependent on fully developed acquired immunity. Measured decreased levels of TGF-beta and an increased amount of alpha-2 macroglobulin in serum contributed to the elucida
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CE - Biochemistry
OECD FORD branch
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Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Applied Biomedicine
ISSN
1214-021X
e-ISSN
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Volume of the periodical
12
Issue of the periodical within the volume
1
Country of publishing house
CZ - CZECH REPUBLIC
Number of pages
9
Pages from-to
39-47
UT code for WoS article
000333504400005
EID of the result in the Scopus database
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