Establishment and functions of DNA methylation in the germline
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60076658%3A12310%2F16%3A43897255" target="_blank" >RIV/60076658:12310/16:43897255 - isvavai.cz</a>
Result on the web
<a href="https://www.futuremedicine.com/doi/10.2217/epi-2016-0056" target="_blank" >https://www.futuremedicine.com/doi/10.2217/epi-2016-0056</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.2217/epi-2016-0056" target="_blank" >10.2217/epi-2016-0056</a>
Alternative languages
Result language
angličtina
Original language name
Establishment and functions of DNA methylation in the germline
Original language description
Epigenetic modifications established during gametogenesis regulate transcription and other nuclear processes in gametes, but also have influences in the zygote, embryo and postnatal life. This is best understood for DNA methylation which, established at discrete regions of the oocyte and sperm genomes, governs genomic imprinting. In this review, we describe how imprinting has informed our understanding of de novo DNA methylation mechanisms, highlight how recent genome-wide profiling studies have provided unprecedented insights into establishment of the sperm and oocyte methylomes and consider the fate and function of gametic methylation and other epigenetic modifications after fertilization.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10608 - Biochemistry and molecular biology
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Epigenomics
ISSN
1750-1911
e-ISSN
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Volume of the periodical
8
Issue of the periodical within the volume
10
Country of publishing house
GB - UNITED KINGDOM
Number of pages
15
Pages from-to
1399-1413
UT code for WoS article
000385653900008
EID of the result in the Scopus database
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