A comparative analysis on the physicochemical properties of tick-borne encephalitis virus envelope protein residues that affect its antigenic properties

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60076658%3A12310%2F17%3A43895762" target="_blank" >RIV/60076658:12310/17:43895762 - isvavai.cz</a>
Alternative codes found
RIV/60077344:_____/17:00478919 RIV/00027162:_____/17:N0000087
Result on the web
<a href="https://ac.els-cdn.com/S0168170217301090/1-s2.0-S0168170217301090-main.pdf?_tid=9e6a6af2-f9cf-11e7-8490-00000aab0f27&acdnat=1516005757_fba3feb43dacde3e6953a9cefea0033b" target="_blank" >https://ac.els-cdn.com/S0168170217301090/1-s2.0-S0168170217301090-main.pdf?_tid=9e6a6af2-f9cf-11e7-8490-00000aab0f27&acdnat=1516005757_fba3feb43dacde3e6953a9cefea0033b</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.virusres.2017.06.006" target="_blank" >10.1016/j.virusres.2017.06.006</a>

Result language
angličtina
Original language name
A comparative analysis on the physicochemical properties of tick-borne encephalitis virus envelope protein residues that affect its antigenic properties
Original language description
This work is dedicated to the study of the variability of the main antigenic envelope protein E among different strains of tick-borne encephalitis virus at the level of physical and chemical properties of the amino acid residues. E protein variants were extracted from then NCBI database. Four amino acid residues properties in the polypeptide sequences were investigated: the average volume of the amino acid residue in the protein tertiary structure, the number of amino acid residue hydrogen bond donors, the charge of amino acid residue lateral radical and the dipole moment of the amino acid residue. These physico-chemical properties are involved in antigen-antibody interactions. As a result, 103 different variants of the antigenic determinants of the tick-borne encephalitis virus E protein were found, significantly different by physical and chemical properties of the amino acid residues in their structure. This means that some strains among the natural variants of tick-borne encephalitis virus can potentially escape the immune response induced by the standard vaccine.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10607 - Virology

Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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