Setd1b, encoding a histone 3 lysine 4 methyltransferase, is a maternal effect gene required for the oogenic gene expression program
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60076658%3A12310%2F17%3A43897257" target="_blank" >RIV/60076658:12310/17:43897257 - isvavai.cz</a>
Result on the web
<a href="http://dev.biologists.org/content/develop/144/14/2606.full.pdf" target="_blank" >http://dev.biologists.org/content/develop/144/14/2606.full.pdf</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1242/dev.143347" target="_blank" >10.1242/dev.143347</a>
Alternative languages
Result language
angličtina
Original language name
Setd1b, encoding a histone 3 lysine 4 methyltransferase, is a maternal effect gene required for the oogenic gene expression program
Original language description
Germ cell development involves major reprogramming of the epigenome to prime the zygote for totipotency. Histone 3 lysine 4 (H3K4) methylations are universal epigenetic marks mediated in mammals by six H3K4 methyltransferases related to fly Trithorax, including two yeast Set1 orthologs: Setd1a and Setd1b. Whereas Setd1a plays no role in oogenesis, we report that Setd1b deficiency causes female sterility in mice. Oocyte-specific Gdf9-iCre conditional knockout (Setd1b(Gdf9)cKO) ovaries developthrough all stages; however, follicular loss accumulated with age and unfertilized metaphase II (MII) oocytesexhibited irregularitiesof thezonapellucida andmeioticspindle. Most Setd1b(Gdf9)cKO zygotes remained in the pronuclear stage and displayed polyspermy in the perivitelline space. Expression profiling of Setd1b(Gdf9) cKO MII oocytes revealed (1) that Setd1b promotes the expression of the major oocyte transcription factors including Obox1, 2, 5, 7, Meis2 and Sall4; and (2) twice as many mRNAs were upregulated than downregulated, suggesting that Setd1b also promotes the expression of negative regulators of oocyte development with multiple Zfp-KRAB factors implicated. Together, these findings indicate that Setd1b serves as maternal effect gene through regulation of the oocyte gene expression program.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10608 - Biochemistry and molecular biology
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Development
ISSN
0950-1991
e-ISSN
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Volume of the periodical
144
Issue of the periodical within the volume
14
Country of publishing house
GB - UNITED KINGDOM
Number of pages
12
Pages from-to
2806-2817
UT code for WoS article
000405701000008
EID of the result in the Scopus database
2-s2.0-85025175377