Alternative assembly of respiratory complex II connects energy stress to metabolic checkpoints

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60076658%3A12310%2F18%3A43897308" target="_blank" >RIV/60076658:12310/18:43897308 - isvavai.cz</a>

Alternative codes found

RIV/86652036:_____/18:00492386 RIV/68378050:_____/18:00492386

Result on the web

<a href="https://www.nature.com/articles/s41467-018-04603-z#author-information" target="_blank" >https://www.nature.com/articles/s41467-018-04603-z#author-information</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1038/s41467-018-04603-z" target="_blank" >10.1038/s41467-018-04603-z</a>

Result language

angličtina

Original language name

Alternative assembly of respiratory complex II connects energy stress to metabolic checkpoints

Original language description

Cell growth and survival depend on a delicate balance between energy production and synthesis of metabolites. Here, we provide evidence that an alternative mitochondrial complex II (CII) assembly, designated as CIIlow, serves as a checkpoint for metabolite biosynthesis under bioenergetic stress, with cells suppressing their energy utilization by modulating DNA synthesis and cell cycle progression. Depletion of CIIlow leads to an imbalance in energy utilization and metabolite synthesis, as evidenced by recovery of the de novo pyrimidine pathway and unlocking cell cycle arrest from the S-phase. In vitro experiments are further corroborated by analysis of paraganglioma tissues from patients with sporadic, SDHA and SDHB mutations. These findings suggest that CIIlow is a core complex inside mitochondria that provides homeostatic control of cellular metabolism depending on the availability of energy.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

10608 - Biochemistry and molecular biology

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2018

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Nature Communications

ISSN

2041-1723

e-ISSN

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Volume of the periodical

9

Issue of the periodical within the volume

JUN 7 2018

Country of publishing house

GB - UNITED KINGDOM

Number of pages

17

Pages from-to

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UT code for WoS article

000434379800018

EID of the result in the Scopus database

2-s2.0-85048232435