Saliva of Ixodes ricinus enhances TBE virus replication in dendritic cells by modulation of pro-survival Akt pathway
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60076658%3A12310%2F18%3A43897549" target="_blank" >RIV/60076658:12310/18:43897549 - isvavai.cz</a>
Alternative codes found
RIV/60077344:_____/18:00498748
Result on the web
<a href="https://reader.elsevier.com/reader/sd/pii/S0042682217303793?token=AE7DE1777BAE40C8829BF93C926D8F02E363602F4B798930CBC4C1C292D2CA27DE83E145D290B2E05EC80B1EA08D6CEF" target="_blank" >https://reader.elsevier.com/reader/sd/pii/S0042682217303793?token=AE7DE1777BAE40C8829BF93C926D8F02E363602F4B798930CBC4C1C292D2CA27DE83E145D290B2E05EC80B1EA08D6CEF</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.virol.2017.11.008" target="_blank" >10.1016/j.virol.2017.11.008</a>
Alternative languages
Result language
angličtina
Original language name
Saliva of Ixodes ricinus enhances TBE virus replication in dendritic cells by modulation of pro-survival Akt pathway
Original language description
It has been suggested that tick saliva facilitates transmission of tick-borne encephalitis virus (TBEV) to vertebrates. The mechanism of this facilitation has not been elucidated yet. Since dendritic cells (DCs) are among first cells attacked by the virus, we examined the amount of virus and changes induced by saliva in TBEV-infected DCs. We found that virus replication was significantly increased by saliva of Ixodes ricinus tick. Next, saliva induced enhancement of Akt pathway activation was observed in TBEV-infected DCs. Akt mediated pathway is known for its anti-apoptotic and pro-survival effects. Accordingly, apoptosis of TBEV-infected DCs was declined and cellular viability increased in the presence of tick saliva. Saliva-induced enhancement of STAT1 and NF-kappa B was also observed in TBEV-infected DCs. In conclusion, we suggest that tick saliva provides pro-survival and anti-apoptotic signals to infected DCs via upregulation of Akt, which may have positive consequences for TBEV replication and transmission.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10607 - Virology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Virology
ISSN
0042-6822
e-ISSN
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Volume of the periodical
514
Issue of the periodical within the volume
JAN 15 2018
Country of publishing house
US - UNITED STATES
Number of pages
8
Pages from-to
98-105
UT code for WoS article
000423010200011
EID of the result in the Scopus database
2-s2.0-85034652583