Biosynthesis of the neurotoxin domoic acid in a bloom-forming diatom
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60076658%3A12310%2F18%3A43897565" target="_blank" >RIV/60076658:12310/18:43897565 - isvavai.cz</a>
Alternative codes found
RIV/60077344:_____/18:00497580
Result on the web
<a href="http://science.sciencemag.org/content/361/6409/1356" target="_blank" >http://science.sciencemag.org/content/361/6409/1356</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1126/science.aau0382" target="_blank" >10.1126/science.aau0382</a>
Alternative languages
Result language
angličtina
Original language name
Biosynthesis of the neurotoxin domoic acid in a bloom-forming diatom
Original language description
Oceanic harmful algal blooms of Pseudo-nitzschia diatoms produce the potent mammalian neurotoxin domoic acid (DA). Despite decades of research, the molecular basis for its biosynthesis is not known. By using growth conditions known to induce DA production in Pseudo-nitzschia multiseries, we implemented transcriptome sequencing in order to identify DA biosynthesis genes that colocalize in a genomic four-gene cluster. We biochemically investigated the recombinant DA biosynthetic enzymes and linked their mechanisms to the construction of DA's diagnostic pyrrolidine skeleton, establishing a model for DA biosynthesis. Knowledge of the genetic basis for toxin production provides an orthogonal approach to bloom monitoring and enables study of environmental factors that drive oceanic DA production.
Czech name
—
Czech description
—
Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
10602 - Biology (theoretical, mathematical, thermal, cryobiology, biological rhythm), Evolutionary biology
Result continuities
Project
<a href="/en/project/GA18-13458S" target="_blank" >GA18-13458S: Evolution and fate of endosymbiotic organelles in stramenopiles</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Science
ISSN
0036-8075
e-ISSN
—
Volume of the periodical
361
Issue of the periodical within the volume
6409
Country of publishing house
US - UNITED STATES
Number of pages
3
Pages from-to
1356-"+"
UT code for WoS article
000446142200025
EID of the result in the Scopus database
2-s2.0-85054137927