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Biosynthesis of the neurotoxin domoic acid in a bloom-forming diatom

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60076658%3A12310%2F18%3A43897565" target="_blank" >RIV/60076658:12310/18:43897565 - isvavai.cz</a>

  • Alternative codes found

    RIV/60077344:_____/18:00497580

  • Result on the web

    <a href="http://science.sciencemag.org/content/361/6409/1356" target="_blank" >http://science.sciencemag.org/content/361/6409/1356</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1126/science.aau0382" target="_blank" >10.1126/science.aau0382</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Biosynthesis of the neurotoxin domoic acid in a bloom-forming diatom

  • Original language description

    Oceanic harmful algal blooms of Pseudo-nitzschia diatoms produce the potent mammalian neurotoxin domoic acid (DA). Despite decades of research, the molecular basis for its biosynthesis is not known. By using growth conditions known to induce DA production in Pseudo-nitzschia multiseries, we implemented transcriptome sequencing in order to identify DA biosynthesis genes that colocalize in a genomic four-gene cluster. We biochemically investigated the recombinant DA biosynthetic enzymes and linked their mechanisms to the construction of DA&apos;s diagnostic pyrrolidine skeleton, establishing a model for DA biosynthesis. Knowledge of the genetic basis for toxin production provides an orthogonal approach to bloom monitoring and enables study of environmental factors that drive oceanic DA production.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    10602 - Biology (theoretical, mathematical, thermal, cryobiology, biological rhythm), Evolutionary biology

Result continuities

  • Project

    <a href="/en/project/GA18-13458S" target="_blank" >GA18-13458S: Evolution and fate of endosymbiotic organelles in stramenopiles</a><br>

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2018

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Science

  • ISSN

    0036-8075

  • e-ISSN

  • Volume of the periodical

    361

  • Issue of the periodical within the volume

    6409

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    3

  • Pages from-to

    1356-"+"

  • UT code for WoS article

    000446142200025

  • EID of the result in the Scopus database

    2-s2.0-85054137927