Combinatorial interplay of RNA-binding proteins tunes levels of mitochondrial mRNA in trypanosomes
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60076658%3A12310%2F18%3A43897636" target="_blank" >RIV/60076658:12310/18:43897636 - isvavai.cz</a>
Alternative codes found
RIV/60077344:_____/18:00498061
Result on the web
<a href="https://rnajournal.cshlp.org/content/24/11/1594" target="_blank" >https://rnajournal.cshlp.org/content/24/11/1594</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1261/rna.066233.118" target="_blank" >10.1261/rna.066233.118</a>
Alternative languages
Result language
angličtina
Original language name
Combinatorial interplay of RNA-binding proteins tunes levels of mitochondrial mRNA in trypanosomes
Original language description
MRP1/2 is a heteromeric protein complex that functions in the trypanosomatid mitochondrion as part of the RNA editing machinery, which facilitates multiple targeted insertions and deletions of uridines. MRP1/2 was shown to interact with MRB8170, which initiates RNA editing by marking pre-edited mRNAs, while TbRGG2 is required for its efficient progression on pan-edited mRNAs. Both MRP1/2 and TbRGG2 are capable of modulating RNA-RNA interactions in vitro. As determined by using iCLIP and RIP-qPCR, RNAs bound to MRP1/2 are characterized and compared with those associated with MRB8170 and TbRGG2. We provide evidence that MRP1 and MRB8170 have correlated binding and similar RNA crosslinking peak profiles over minimally and never-edited mRNAs. Our results suggest that MRP1 assists MRB8170 in RNA editing on minimally edited mRNAs.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10608 - Biochemistry and molecular biology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
RNA-A Publication of the RNA Society
ISSN
1355-8382
e-ISSN
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Volume of the periodical
24
Issue of the periodical within the volume
11
Country of publishing house
US - UNITED STATES
Number of pages
13
Pages from-to
1594-1606
UT code for WoS article
000447362100015
EID of the result in the Scopus database
2-s2.0-85055075373