Wwc2Is a Novel Cell Division Regulator During Preimplantation Mouse Embryo Lineage Formation and Oogenesis
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60076658%3A12310%2F20%3A43901140" target="_blank" >RIV/60076658:12310/20:43901140 - isvavai.cz</a>
Alternative codes found
RIV/67985904:_____/20:00533450
Result on the web
<a href="https://pubmed.ncbi.nlm.nih.gov/33042987/" target="_blank" >https://pubmed.ncbi.nlm.nih.gov/33042987/</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3389/fcell.2020.00857" target="_blank" >10.3389/fcell.2020.00857</a>
Alternative languages
Result language
angličtina
Original language name
Wwc2Is a Novel Cell Division Regulator During Preimplantation Mouse Embryo Lineage Formation and Oogenesis
Original language description
Formation of the hatching mouse blastocyst marks the end of preimplantation development, whereby previous cell cleavages culminate in the formation of three distinct cell lineages (trophectoderm, primitive endoderm and epiblast). We report that dysregulated expression ofWwc2, a genetic paralog ofKibra/Wwc1(a known activator of Hippo-signaling, a key pathway during preimplantation development), is specifically associated with cell autonomous deficits in embryo cell number and cell division abnormalities. Division phenotypes are also observed during mouse oocyte meiotic maturation, asWwc2dysregulation blocks progression to the stage of meiosis II metaphase (MII) arrest and is associated with spindle defects and failed Aurora-A kinase (AURKA) activation. Oocyte and embryo cell division defects, each occurring in the absence of centrosomes, are fully reversible by expression of recombinant HA-epitope tagged WWC2, restoring activated oocyte AURKA levels. Additionally, clonal embryonic dysregulation implicatesWwc2in maintaining the pluripotent epiblast lineage. Thus,Wwc2is a novel regulator of meiotic and early mitotic cell divisions, and mouse blastocyst cell fate.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10608 - Biochemistry and molecular biology
Result continuities
Project
<a href="/en/project/GA18-02891S" target="_blank" >GA18-02891S: Regulating the balance between differentiation and pluripotency; molecular characterisation of p38-MAPK function in mouse blastocyst ICM maturation.</a><br>
Continuities
S - Specificky vyzkum na vysokych skolach
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Frontiers in Cell and Developmental Biology
ISSN
2296-634X
e-ISSN
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Volume of the periodical
8
Issue of the periodical within the volume
SEP 17 2020
Country of publishing house
CH - SWITZERLAND
Number of pages
20
Pages from-to
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UT code for WoS article
000576814000001
EID of the result in the Scopus database
2-s2.0-85091940514