Gas-aggregated Ag nanoparticles for detection of small molecules using LDI MS

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60076658%3A12310%2F20%3A43901186" target="_blank" >RIV/60076658:12310/20:43901186 - isvavai.cz</a>

Alternative codes found

RIV/60077344:_____/20:00540037

Result on the web

<a href="https://link.springer.com/article/10.1007%2Fs00216-019-02329-5" target="_blank" >https://link.springer.com/article/10.1007%2Fs00216-019-02329-5</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s00216-019-02329-5" target="_blank" >10.1007/s00216-019-02329-5</a>

Result language

angličtina

Original language name

Gas-aggregated Ag nanoparticles for detection of small molecules using LDI MS

Original language description

Several reports demonstrate that silver nanomaterials can serve as surface-assisted laser desorption ionization mass spectrometry (SALDI MS) substrates for low molecular weight analytes. Substrate with tailored silver nanostructures, primarily representing the upmost layer of the bulk, i.e., occurring beneath the analyzed medium, limits the use of silver only for desorption enhancement; the charge transfer progresses through atoms from the absorbing analyte or an additional matrix (resulting in the formation of analyte/hydrogen, sodium, or potassium adducts in the most cases). In the presented approach, we utilize a homogeneous layer of silver nanoparticles, prepared under low-pressure conditions, deposited onto a dried analyte. We demonstrate that the nanoparticle layer can fully replace a matrix typically used for the detection of small molecules by laser desorption/ionization mass spectrometry-based technique (LDI MS) and can be applied to the already prepared samples. Various chemical species were detected as [M + Ag](+) adduct ions employing the proposed technique. The normalized signal of the analyte/silver adduct can be utilized to characterize a quantitative presence of analytes on the surface similar to signal-to-noise value, here demonstrated by the detection of trimethoprim molecule. This study also includes a detailed description of additional features one needs to take into account, such as a formation of [M-x + Ag-y](+) adducts, presence of silver ions (can be used for m/z calibration), analyte fragmentation, and influence of deposited nanoparticles quantity on the signal intensity.

Czech name

—

Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

21001 - Nano-materials (production and properties)

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2020

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Analytical and Bioanalytical Chemistry

ISSN

1618-2642

e-ISSN

—

Volume of the periodical

412

Issue of the periodical within the volume

5

Country of publishing house

DE - GERMANY

Number of pages

11

Pages from-to

1037-1047

UT code for WoS article

000519760900001

EID of the result in the Scopus database

2-s2.0-85076621931