An innovative and eco-friendly modality for synthesis of highly fluorinated graphene by an acidic ionic liquid: Making of an efficacious vehicle for anti-cancer drug delivery
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60076658%3A12310%2F20%3A43901279" target="_blank" >RIV/60076658:12310/20:43901279 - isvavai.cz</a>
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S0169433220308278?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0169433220308278?via%3Dihub</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.apsusc.2020.146071" target="_blank" >10.1016/j.apsusc.2020.146071</a>
Alternative languages
Result language
angličtina
Original language name
An innovative and eco-friendly modality for synthesis of highly fluorinated graphene by an acidic ionic liquid: Making of an efficacious vehicle for anti-cancer drug delivery
Original language description
Fluorination of graphene nanomaterials has multitude merits owing to the peculiar temperament of the carbonfluorine (C-F) bond. However, the current synthesis modalities of fluorinated graphene (FG) are based on the usage of toxic materials at high temperatures, which are problematic to be used. The methods to overcome these problems are challenging for chemists. Ionic liquids (ILs) have been used in several chemical processes as auxiliaries and eco-friendly alternatives instead of volatile organic solvents because of their properties. Consequently, herein we exploited a highly effective and green process for the synthesis of FG at mild temperature (80 degrees C) by using ammonium fluoride salt as fluorine agent and a synthesized acidic IL ([TEA](+) [TFA](-)) as a solvent. Our goal was to synthesize enriched FG with a high degree of fluorination (66.4 wt% of F) and F/C ratio (2.2), which measured and confirmed by XPS analysis. Subsequently, the obtained FG was used as a nanocarrier for delivery of curcumin to cancerous cells. The in-vitro results showed that these nanosheets possessed a higher Cur-loading efficiency (78.43%) than commercial FG (52.12%) due to the sheet-like structure with folded edges. This, in turn, translated into an excellent in-vitro anti-cancer effect when tested against cancerous cells.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10403 - Physical chemistry
Result continuities
Project
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Continuities
S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Applied surface science
ISSN
0169-4332
e-ISSN
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Volume of the periodical
515
Issue of the periodical within the volume
JUN 15 2020
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
11
Pages from-to
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UT code for WoS article
000525637300008
EID of the result in the Scopus database
2-s2.0-85081967484