Diverse telomeres in trypanosomatids
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60076658%3A12310%2F21%3A43903164" target="_blank" >RIV/60076658:12310/21:43903164 - isvavai.cz</a>
Alternative codes found
RIV/61988987:17310/21:A2202AEC RIV/60077344:_____/21:00554492 RIV/00216208:11310/21:10430992
Result on the web
<a href="https://www.cambridge.org/core/journals/parasitology/article/diverse-telomeres-in-trypanosomatids/A5F22C810DA8F772B7CB884834EB325E#" target="_blank" >https://www.cambridge.org/core/journals/parasitology/article/diverse-telomeres-in-trypanosomatids/A5F22C810DA8F772B7CB884834EB325E#</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1017/S0031182021000378" target="_blank" >10.1017/S0031182021000378</a>
Alternative languages
Result language
angličtina
Original language name
Diverse telomeres in trypanosomatids
Original language description
Telomeres are the ends of linear eukaryotic chromosomes facilitating the resolution of the 'end replication and protection' problems, associated with linearity. At the nucleotide level, telomeres typically represent stretches of tandemly arranged telomeric repeats, which vary in length and sequence among different groups of organisms. Recently, a composition of the telomere-associated protein complex has been scrutinized in Trypanosoma brucei. In this work, we subjected proteins from that list to a more detailed bioinformatic analysis and delineated a core set of 20 conserved proteins putatively associated with telomeres in trypanosomatids. Out of these, two proteins (Ku70 and Ku80) are conspicuously missing in representatives of the genus Blastocrithidia, yet telomeres in these species do not appear to be affected. In this work, based on the analysis of a large set of trypanosomatids widely different in their phylogenetic position and life strategies, we demonstrated that telomeres of trypanosomatids are diverse in length, even within groups of closely related species. Our analysis showed that the expression of two proteins predicted to be associated with telomeres (those encoding telomerase and telomere-associated hypothetical protein orthologous to Tb927.6.4330) may directly affect and account for the differences in telomere length within the species of the Leishmania mexicana complex.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10606 - Microbiology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Parasitology
ISSN
0031-1820
e-ISSN
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Volume of the periodical
148
Issue of the periodical within the volume
10
Country of publishing house
US - UNITED STATES
Number of pages
17
Pages from-to
1254-1270
UT code for WoS article
000674635600015
EID of the result in the Scopus database
2-s2.0-85102705137