Structural and biochemical characterization of the novel serpin Iripin-5 from Ixodes ricinus
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60076658%3A12310%2F21%3A43903274" target="_blank" >RIV/60076658:12310/21:43903274 - isvavai.cz</a>
Alternative codes found
RIV/60077344:_____/21:00554123
Result on the web
<a href="https://scripts.iucr.org/cgi-bin/paper?S2059798321007920" target="_blank" >https://scripts.iucr.org/cgi-bin/paper?S2059798321007920</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1107/S2059798321007920" target="_blank" >10.1107/S2059798321007920</a>
Alternative languages
Result language
angličtina
Original language name
Structural and biochemical characterization of the novel serpin Iripin-5 from Ixodes ricinus
Original language description
Iripin-5 is the main Ixodes ricinus salivary serpin, which acts as a modulator of host defence mechanisms by impairing neutrophil migration, suppressing nitric oxide production by macrophages and altering complement functions. Iripin-5 influences host immunity and shows high expression in the salivary glands. Here, the crystal structure of Iripin-5 in the most thermodynamically stable state of serpins is described. In the reactive-centre loop, the main substrate-recognition site of Iripin-5 is likely to be represented by Arg342, which implies the targeting of trypsin-like proteases. Furthermore, a computational structural analysis of selected Iripin-5-protease complexes together with interface analysis revealed the most probable residues of Iripin-5 involved in complex formation.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10608 - Biochemistry and molecular biology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Acta crystallographica. Section D - Structural Biology
ISSN
2059-7983
e-ISSN
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Volume of the periodical
77
Issue of the periodical within the volume
SEP 1 2021
Country of publishing house
US - UNITED STATES
Number of pages
14
Pages from-to
1183-1196
UT code for WoS article
000693083600006
EID of the result in the Scopus database
2-s2.0-85114043140