Competition between strains of Borrelia afzelii in the host tissues and consequences for transmission to ticks

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60076658%3A12310%2F21%3A43903628" target="_blank" >RIV/60076658:12310/21:43903628 - isvavai.cz</a>

Alternative codes found

RIV/60077344:_____/21:00553209

Result on the web

<a href="https://www.nature.com/articles/s41396-021-00939-5" target="_blank" >https://www.nature.com/articles/s41396-021-00939-5</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1038/s41396-021-00939-5" target="_blank" >10.1038/s41396-021-00939-5</a>

Result language

angličtina

Original language name

Competition between strains of Borrelia afzelii in the host tissues and consequences for transmission to ticks

Original language description

Pathogen species often consist of genetically distinct strains, which can establish mixed infections or coinfections in the host. In coinfections, interactions between pathogen strains can have important consequences for their transmission success. We used the tick-borne bacterium Borrelia afzelii, which is the most common cause of Lyme disease in Europe, as a model multi-strain pathogen to investigate the relationship between coinfection, competition between strains, and strain-specific transmission success. Mus musculus mice were infected with one or two strains of B. afzelii, strain transmission success was measured by feeding ticks on mice, and the distribution of each strain in six different mouse organs and the ticks was measured using qPCR. Coinfection and competition reduced the tissue infection prevalence of both strains and changed their bacterial abundance in some tissues. Coinfection and competition also reduced the transmission success of the B. afzelii strains from the infected hosts to feeding ticks. The ability of the B. afzelii strains to establish infection in the host tissues was strongly correlated with their transmission success to the tick vector. Our study demonstrates that coinfection and competition between pathogen strains inside the host tissues can have major consequences for their transmission success.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

10606 - Microbiology

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2021

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

I S M E Journal

ISSN

1751-7362

e-ISSN

—

Volume of the periodical

15

Issue of the periodical within the volume

8

Country of publishing house

GB - UNITED KINGDOM

Number of pages

11

Pages from-to

2390-2400

UT code for WoS article

000625051100002

EID of the result in the Scopus database

2-s2.0-85102108514