Intratumoral immunotherapy of murine pheochromocytoma shows no age-dependent differences in its efficacy
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60076658%3A12310%2F23%3A43906544" target="_blank" >RIV/60076658:12310/23:43906544 - isvavai.cz</a>
Result on the web
<a href="https://www.frontiersin.org/articles/10.3389/fendo.2023.1030412/full" target="_blank" >https://www.frontiersin.org/articles/10.3389/fendo.2023.1030412/full</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3389/fendo.2023.1030412" target="_blank" >10.3389/fendo.2023.1030412</a>
Alternative languages
Result language
angličtina
Original language name
Intratumoral immunotherapy of murine pheochromocytoma shows no age-dependent differences in its efficacy
Original language description
Cancer immunotherapy has shown remarkable clinical progress in recent years. Although age is one of the biggest leading risk factors for cancer development and older adults represent a majority of cancer patients, only a few new cancer immunotherapeutic interventions have been preclinically tested in aged animals. Thus, the lack of preclinical studies focused on age-dependent effect during cancer immunotherapy could lead to different therapeutic outcomes in young and aged animals and future modifications of human clinical trials. Here, we compare the efficacy of previously developed and tested intratumoral immunotherapy, based on the combination of polysaccharide mannan, toll-like receptor ligands, and anti-CD40 antibody (MBTA immunotherapy), in young (6 weeks) and aged (71 weeks) mice bearing experimental pheochromocytoma (PHEO). The presented results point out that despite faster growth of PHEO in aged mice MBTA intratumoral immunotherapy is effective approach without age dependence and could be one of the possible therapeutic interventions to enhance immune response to pheochromocytoma and perhaps other tumor types in aged and young hosts.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30102 - Immunology
Result continuities
Project
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Continuities
S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
FRONTIERS IN ENDOCRINOLOGY
ISSN
1664-2392
e-ISSN
1664-2392
Volume of the periodical
14
Issue of the periodical within the volume
MAY 8 2023
Country of publishing house
CH - SWITZERLAND
Number of pages
7
Pages from-to
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UT code for WoS article
001008051800001
EID of the result in the Scopus database
2-s2.0-85159909226