Insight Into the Dynamics of the Ixodes ricinus Nymphal Midgut Proteome
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60076658%3A12310%2F23%3A43907840" target="_blank" >RIV/60076658:12310/23:43907840 - isvavai.cz</a>
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S1535947623001743?via%3Dihub#kwrds0010" target="_blank" >https://www.sciencedirect.com/science/article/pii/S1535947623001743?via%3Dihub#kwrds0010</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.mcpro.2023.100663" target="_blank" >10.1016/j.mcpro.2023.100663</a>
Alternative languages
Result language
angličtina
Original language name
Insight Into the Dynamics of the Ixodes ricinus Nymphal Midgut Proteome
Original language description
Ticks are ectoparasites that feed on blood and have an impressive ability to consume and process enormous amounts of host blood, allowing extremely long periods of starvation between blood meals. The central role in the parasitic lifestyle of ticks is played by the midgut. This organ efficiently stores and digests ingested blood and serves as the primary interface for the transmission of tick -borne pathogens. In this study, we used a label -free quantitative approach to perform a novel dynamic proteomic analysis of the midgut of Ixodesricinus nymphs, covering their development from unfed to pre -molt stages. We identified 1534 I. ricinus-specific proteins with a relatively low proportion of host proteins. This proteome dataset, which was carefully examined by manual scrutiny, allowed precise annotation of proteins important for blood meal processing and their dynamic changes during nymphal ontogeny. We focused on midgut molecules related to lipid hydrolysis, storage, and transport, opening a yet unexplored avenue for studying lipid metabolism in ticks. Further dynamic profiling of the tick's multi -enzyme digestive network, protease inhibitors, enzymes involved in redox homeostasis and detoxification, antimicrobial peptides, and proteins responsible for midgut colonization by Borrelia spirochetes promises to uncover new targets for targeting tick nymphs, the most critical life stage for transmission the pathogens that cause tick -borne diseases.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10607 - Virology
Result continuities
Project
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Continuities
S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Molecular & Cellular Proteomics
ISSN
1535-9484
e-ISSN
1535-9484
Volume of the periodical
22
Issue of the periodical within the volume
11
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
28
Pages from-to
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UT code for WoS article
001162967500001
EID of the result in the Scopus database
2-s2.0-85178499359