Role of B cells in intratumoral MBTA immunotherapy of murine pheochromocytoma model

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60076658%3A12310%2F25%3A43909959" target="_blank" >RIV/60076658:12310/25:43909959 - isvavai.cz</a>

Alternative codes found

RIV/00216224:14110/25:00140736 RIV/00216208:11110/25:10497208

Result on the web

<a href="https://www.sciencedirect.com/science/article/pii/S1521690X24001179?pes=vor&utm_source=clarivate&getft_integrator=clarivate" target="_blank" >https://www.sciencedirect.com/science/article/pii/S1521690X24001179?pes=vor&utm_source=clarivate&getft_integrator=clarivate</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.beem.2024.101941" target="_blank" >10.1016/j.beem.2024.101941</a>

Result language

angličtina

Original language name

Role of B cells in intratumoral MBTA immunotherapy of murine pheochromocytoma model

Original language description

Immunotherapy represents a revolutionary advancement in cancer treatment, which has traditionally focused on T cells; however, the role of B cells in cancer immunotherapy has gained interest because of their role in antigen presentation, antibody production, and cytokine release. In this study, we examined the role of B cells in previously developed intratumoral MBTA therapy (mannan-BAM, TLR ligands, and anti-CD40 antibody) in murine models of MTT pheochromocytoma. The results indicated that B cells significantly enhance the success of MBTA therapy, with wild-type mice exhibiting a lower tumor incidence and smaller tumors compared with B cell-deficient mice. Increased IL-6 and TNF-alpha levels indicated severe inflammation and a potential cytokine storm in B cell-deficient mice. Neutralization of TNF-alpha ameliorated these complications but resulted in increased tumor recurrence. The results highlight the important role of B cells in enhancing the immune response and maintaining immune homeostasis during MBTA therapy. Our findings offer new insights into improving therapeutic outcomes.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30102 - Immunology

Project

<a href="/en/project/LUAUS24120" target="_blank" >LUAUS24120: Synergistic targeting of hallmarks of cancer cells and their microenvironment</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2025

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

BEST PRACTICE &amp; RESEARCH CLINICAL ENDOCRINOLOGY &amp; METABOLISM

ISSN

1521-690X

e-ISSN

1532-1908

Volume of the periodical

39

Issue of the periodical within the volume

1

Country of publishing house

GB - UNITED KINGDOM

Number of pages

10

Pages from-to

nestránkováno

UT code for WoS article

001420745200001

EID of the result in the Scopus database

2-s2.0-85203831067