Physiological condition status and Muscle based biomarkers in rainbow trout (Oncorhynchus mykiss), after long-term exposure to carbamazepine

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60076658%3A12520%2F10%3A00011403" target="_blank" >RIV/60076658:12520/10:00011403 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Physiological condition status and Muscle based biomarkers in rainbow trout (Oncorhynchus mykiss), after long-term exposure to carbamazepine

Original language description

The chronic toxic effects of carbamazepine (CBZ) on rainbow trout were investigated. Fish were exposed at sublethal concentrations of CBZ (1.0 ?g.l-1, 0.2 mg l-1 and 2.0 mg.l-1) for 42 days. Compared with the control, there was a significant lower (P < 0.05) condition factor in fish exposed at the highest concentration of CBZ (2.0 mg.l-1), but the hepatosomatic indices in all groups were not significant changes. At lower CBZ concentration (1.0 ?g.l-1, 0.2 mg.l-1), the antioxidant enzyme activities wereinduced slightly, except catalase, while at the highest concentration (2.0 mg.l-1) oxidative stress was apparent as reflected by the significant higher lipid peroxidation and protein carbonyls in the fish muscle, associated with a significant inhibitionof antioxidant enzymes activities. Moreover, energy metabolic parameters (RNA-DNA ratio, Na+-K+-ATPase) were significantly inhibited in muscle of the fish exposed at the highest concentration (2.0 mg.l-1), compared with the control.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

GL - Fishery

OECD FORD branch

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Project

<a href="/en/project/SP%2F2E7%2F229%2F07" target="_blank" >SP/2E7/229/07: Anthropogenic pressures on the status of soils, water resources and water ecosystems in the Czech part of the international basin of the Elbe River</a><br>

Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2010

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Applied Toxicology

ISSN

0260-437X

e-ISSN

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Volume of the periodical

30

Issue of the periodical within the volume

3

Country of publishing house

GB - UNITED KINGDOM

Number of pages

7

Pages from-to

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UT code for WoS article

000277524000002

EID of the result in the Scopus database

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