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Comparison of three fluorescent CYP3A substrates in two vertebrate models: pig and Atlantic salmon

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60076658%3A12520%2F12%3A43883434" target="_blank" >RIV/60076658:12520/12:43883434 - isvavai.cz</a>

  • Result on the web

    <a href="http://dx.doi.org/10.1017/S1751731111002096" target="_blank" >http://dx.doi.org/10.1017/S1751731111002096</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1017/S1751731111002096" target="_blank" >10.1017/S1751731111002096</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Comparison of three fluorescent CYP3A substrates in two vertebrate models: pig and Atlantic salmon

  • Original language description

    We investigated in vitro inhibitory effects of ketoconazole (KTZ) on cytochrome P450 activity in microsomes from pigs and Atlantic salmon. The following enzymatic reactions were studied: 7-benzyloxyresorufin and 7-ethoxyresorufin O-dealkylation (BROD andEROD, respectively), 7-benzyloxy-4-trifluoromethylcoumarin O-debenzylation (BFCOD) and 7-benzyloxyquinoline O-debenzylation (BQOD). KTZ was a potent non-competitive inhibitor of BROD and BQOD in the microsomes from pigs, whereas in the microsomes from Atlantic salmon, these reactions were competitively inhibited by KTZ. BFCOD activity was inhibited by KTZ in a non-competitive manner in both species. KTZ non-competitively inhibited EROD in Atlantic salmon, but not in porcine microsomes. The activity ofBROD and BQOD was higher in male than that in female pigs, but the activity of BFCOD showed no sex-related differences.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    CE - Biochemistry

  • OECD FORD branch

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Others

  • Publication year

    2012

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Animal

  • ISSN

    1751-7311

  • e-ISSN

  • Volume of the periodical

    6

  • Issue of the periodical within the volume

    4

  • Country of publishing house

    GB - UNITED KINGDOM

  • Number of pages

    8

  • Pages from-to

    633-640

  • UT code for WoS article

    000300714200014

  • EID of the result in the Scopus database