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Verapamil does not modify catalytic activity of CYP450 in rainbow trout after long-term exposure

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60076658%3A12520%2F12%3A43883467" target="_blank" >RIV/60076658:12520/12:43883467 - isvavai.cz</a>

  • Result on the web

    <a href="http://dx.doi.org/10.1016/j.ecoenv.2011.12.012" target="_blank" >http://dx.doi.org/10.1016/j.ecoenv.2011.12.012</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1016/j.ecoenv.2011.12.012" target="_blank" >10.1016/j.ecoenv.2011.12.012</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Verapamil does not modify catalytic activity of CYP450 in rainbow trout after long-term exposure

  • Original language description

    Little is known about the effects of the cardiovascular drug verapamil (VRP) on metabolic processes in fish. Most calcium channel blockers including VRP are metabolized by cytochrome P450 (CYP450) enzymes. In this study we investigated the in vivo effectof VRP on some CYP450-mediated reactions in juvenile rainbow trout (Oncorhynchus mykiss). Fish were exposed to sublethal concentrations of VRP (0.5, 27 and 270 mu g l(-1)) for 0, 21, and 42 day. The following CYP450-mediated reactions were studied in hepatic microsomes: O-dealkylation of ethoxyresorufin, methoxyresorufin, and pentoxyresorufin, hydroxylation of coumarin, tolbutamide, and p-nitrophenol, and O-debenzylation of 7-benzyloxy-4-trifluoromethylcoumarin. The amounts of products of these reactions did not differ among fish exposed to different levels of VRP and control fish. This suggests that the levels of VPR used did not alter catalytic activity of the selected CYP450 enzymes. In conclusion, none of the investigated CYP450-me

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    GL - Fishery

  • OECD FORD branch

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach

Others

  • Publication year

    2012

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

  • ISSN

    0147-6513

  • e-ISSN

  • Volume of the periodical

    79

  • Issue of the periodical within the volume

    05

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    5

  • Pages from-to

    148-152

  • UT code for WoS article

    000302107000021

  • EID of the result in the Scopus database