Ascidians: An Emerging Marine Model for Drug Discovery and Screening
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60076658%3A12520%2F17%3A43895339" target="_blank" >RIV/60076658:12520/17:43895339 - isvavai.cz</a>
Result on the web
<a href="http://www.eurekaselect.com/149607/article" target="_blank" >http://www.eurekaselect.com/149607/article</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.2174/1568026617666170130104922" target="_blank" >10.2174/1568026617666170130104922</a>
Alternative languages
Result language
angličtina
Original language name
Ascidians: An Emerging Marine Model for Drug Discovery and Screening
Original language description
Ascidians (tunicates; sea squirts) are marine animals which provide a source of diverse, bioactive natural products, and a model for toxicity screenings. Compounds isolated from ascidians comprise an approved anti-tumor drug and many others are potent drug leads. Furthermore, the use of invertebrate embryos for toxicological screening tests or analysis offers the possibility to image a large number of samples for high throughput screens. Ascidians are members of a sister clade to the vertebrates and make a vertebrate-like tadpole larva composed of less than 3000 cells in 18 hours. The neural complex of the ascidian larva is made of only 350 cells (of which 100 are neurons) and functional genomic studies have now uncovered numerous GRNs underpinning neural specification and differentiation. Numerous studies showed that brain formation in ascidians is sensitive to toxic insults especially from endocrine disruptors making them a suitable model to study neurodevelopmental defects. Modern techniques available for ascidians, including transgenic embryos where 3D time lapse imaging of GFP-expressing reporter constructs can be analyzed, now permit numerous end-points to be evaluated in order to test the specific mode of action of many compounds. This review summarizes the key evidence suggesting that ascidian embryos are a favorable embryological model to study neurodevelopmental toxicity of different compounds with molecular and cellular end-points. We predict that ascidians may become a significant source of marine blue biotechnologies in the 21(st) century.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10511 - Environmental sciences (social aspects to be 5.7)
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Current Topics in Medicinal Chemistry
ISSN
1568-0266
e-ISSN
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Volume of the periodical
17
Issue of the periodical within the volume
18
Country of publishing house
AE - UNITED ARAB EMIRATES
Number of pages
11
Pages from-to
2056-2066
UT code for WoS article
000403825700005
EID of the result in the Scopus database
2-s2.0-85021121380