Disc vs. Annulus: On the Bleaching Pattern Optimization for FRAP Experiments

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60076658%3A12520%2F18%3A43897287" target="_blank" >RIV/60076658:12520/18:43897287 - isvavai.cz</a>
Alternative codes found
RIV/67985807:_____/18:00492042
Result on the web
<a href="https://link.springer.com/chapter/10.1007/978-3-319-97136-0_12" target="_blank" >https://link.springer.com/chapter/10.1007/978-3-319-97136-0_12</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/978-3-319-97136-0_12" target="_blank" >10.1007/978-3-319-97136-0_12</a>

Result language
angličtina
Original language name
Disc vs. Annulus: On the Bleaching Pattern Optimization for FRAP Experiments
Original language description
This study deals with the problem of optimal setting of experimental design variables, which controls the accuracy of the numerical process of determining model parameters from data. Our approach, although case independent, is formulated as an inverse problem of a diffusion coefficient estimation using the FRAP (Fluorescence Recovery After Photobleaching) experimental technique. The key concept relies on the analysis of the sensitivity of the measured output with respect to the model parameters. Based on this idea, we optimize an xperimental design factor being the initial concentration of some particles. Numerical experiments on a 2D finite domain show that the discretized optimal initial condition attains only two values representing the existence or non-existence of diffusive particles. The number of umps between these values determines the connectivity (or the bleaching pattern) and is dependent on the value of a diffusion coefficient, e.g., the annulus shaped initial condition is better than a disc for some specific range of model parameters.
Czech name
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Czech description
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Article name in the collection
High Performance Computing in Science and Engineering
ISBN
978-3-319-97135-3
ISSN
0302-9743
e-ISSN
1611-3349
Number of pages
14
Pages from-to
160-173
Publisher name
Springer Verlag
Place of publication
neuveden
Event location
Karolinka; Czech Republic
Event date
May 22, 2017
Type of event by nationality
EUR - Evropská akce
UT code for WoS article
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