Spatio-temporal assessment of illicit drug use at large scale: evidence from 7 years of international wastewater monitoring
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60076658%3A12520%2F20%3A43900809" target="_blank" >RIV/60076658:12520/20:43900809 - isvavai.cz</a>
Result on the web
<a href="https://doi.org/10.1111/add.14767" target="_blank" >https://doi.org/10.1111/add.14767</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1111/add.14767" target="_blank" >10.1111/add.14767</a>
Alternative languages
Result language
angličtina
Original language name
Spatio-temporal assessment of illicit drug use at large scale: evidence from 7 years of international wastewater monitoring
Original language description
Background and aimsWastewater-based epidemiology is an additional indicator of drug use that is gaining reliability to complement the current established panel of indicators. The aims of this study were to: (i) assess spatial and temporal trends of population-normalized mass loads of benzoylecgonine, amphetamine, methamphetamine and 3,4-methylenedioxymethamphetamine (MDMA) in raw wastewater over 7 years (2011-17); (ii) address overall drug use by estimating the average number of combined doses consumed per day in each city; and (iii) compare these with existing prevalence and seizure data. DesignAnalysis of daily raw wastewater composite samples collected over 1 week per year from 2011 to 2017. Setting and ParticipantsCatchment areas of 143 wastewater treatment plants in 120 cities in 37 countries. MeasurementsParent substances (amphetamine, methamphetamine and MDMA) and the metabolites of cocaine (benzoylecgonine) and of Delta(9)-tetrahydrocannabinol (11-nor-9-carboxy-Delta(9)-tetrahydrocannabinol) were measured in wastewater using liquid chromatography-tandem mass spectrometry. Daily mass loads (mg/day) were normalized to catchment population (mg/1000 people/day) and converted to the number of combined doses consumed per day. Spatial differences were assessed world-wide, and temporal trends were discerned at European level by comparing 2011-13 drug loads versus 2014-17 loads. FindingsBenzoylecgonine was the stimulant metabolite detected at higher loads in southern and western Europe, and amphetamine, MDMA and methamphetamine in East and North-Central Europe. In other continents, methamphetamine showed the highest levels in the United States and Australia and benzoylecgonine in South America. During the reporting period, benzoylecgonine loads increased in general across Europe, amphetamine and methamphetamine levels fluctuated and MDMA underwent an intermittent upsurge. ConclusionsThe analysis of wastewater to quantify drug loads provides near real-time drug use estimates that globally correspond to prevalence and seizure data.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30302 - Epidemiology
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Addiction
ISSN
0965-2140
e-ISSN
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Volume of the periodical
115
Issue of the periodical within the volume
1
Country of publishing house
US - UNITED STATES
Number of pages
12
Pages from-to
109-120
UT code for WoS article
000494149500001
EID of the result in the Scopus database
2-s2.0-85074608360