Neuroactive drugs and other pharmaceuticals found in blood plasma of wild European fish
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60076658%3A12520%2F21%3A43902489" target="_blank" >RIV/60076658:12520/21:43902489 - isvavai.cz</a>
Result on the web
<a href="https://doi.org/10.1016/j.envint.2020.106188" target="_blank" >https://doi.org/10.1016/j.envint.2020.106188</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.envint.2020.106188" target="_blank" >10.1016/j.envint.2020.106188</a>
Alternative languages
Result language
angličtina
Original language name
Neuroactive drugs and other pharmaceuticals found in blood plasma of wild European fish
Original language description
To gain a better understanding of which pharmaceuticals could pose a risk to fish, 94 pharmaceuticals representing 23 classes were analyzed in blood plasma from wild bream, chub, and roach captured at 18 sites in Germany, the Czech Republic and the UK, respectively. Based on read across from humans, we evaluated the risks of pharmacological effects occurring in the fish for each measured pharmaceutical. Twenty-three compounds were found in fish plasma, with the highest levels measured in chub from the Czech Republic. None of the German bream had detectable levels of pharmaceuticals, whereas roach from the Thames had mostly low concentrations. For two pharmaceuticals, four individual Czech fish had plasma concentrations higher than the concentrations reached in the blood of human patients taking the corresponding medication. For nine additional compounds, determined concentrations exceeded 10% of the corresponding human therapeutic plasma concentration in 12 fish. The majority of the pharmaceuticals where a clear risk for pharmacological effects was identified targets the central nervous system. These include e.g. flupentixol, haloperidol, and risperidone, all of which have the potential to affect fish behavior. In addition to identifying pharmaceuticals of environmental concern, the results emphasize the value of environmental monitoring of internal drug levels in aquatic wildlife, as well as the need for more research to establish concentration-response relationships.
Czech name
—
Czech description
—
Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
10511 - Environmental sciences (social aspects to be 5.7)
Result continuities
Project
<a href="/en/project/GA20-09951S" target="_blank" >GA20-09951S: Exciting freshwaters - complex responses of aquatic animals to psychoactive substances present in urbanized waters</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Environment International
ISSN
0160-4120
e-ISSN
—
Volume of the periodical
146
Issue of the periodical within the volume
neuveden
Country of publishing house
GB - UNITED KINGDOM
Number of pages
7
Pages from-to
—
UT code for WoS article
000604625100003
EID of the result in the Scopus database
2-s2.0-85092916978